Detailed information of TA system TA113923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 5131894..5132410
• Replicon: chromosome
• Accession: NZ_CP033631
• Organism: Klebsiella sp. P1CD1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DTA24_RS25335
• Protein ID: WP_022065401.1
• Coordinates: 5131894..5132178 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: DTA24_RS25340
• Protein ID: WP_002886901.1
• Coordinates: 5132168..5132410 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DTA24_RS25320	5126997..5128652	+	1656	WP_077139002.1	alpha,alpha-phosphotrehalase	-
DTA24_RS25325	5129038..5131176	+	2139	WP_077139001.1	anaerobic ribonucleoside-triphosphate reductase	-
DTA24_RS25330	5131426..5131890	+	465	WP_022065402.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
DTA24_RS25335	5131894..5132178	-	285	WP_022065401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DTA24_RS25340	5132168..5132410	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DTA24_RS25345	5132488..5134398	-	1911	WP_032731805.1	BglG family transcription antiterminator	-
DTA24_RS25350	5134421..5135575	-	1155	WP_123837121.1	lactonase family protein	-
DTA24_RS25355	5135701..5136441	-	741	WP_008807137.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11128.97 Da
• Isoelectric Point: 10.2849

>T113923 WP_022065401.1 NZ_CP033631:c5132178-5131894 [Klebsiella sp. P1CD1]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T113923 NZ_CP033631:c5132178-5131894 [Klebsiella sp. P1CD1]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGATGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT113923 WP_002886901.1 NZ_CP033631:c5132410-5132168 [Klebsiella sp. P1CD1]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT113923 NZ_CP033631:c5132410-5132168 [Klebsiella sp. P1CD1]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0