Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4410512..4411131 Replicon chromosome
Accession NZ_CP033631
Organism Klebsiella sp. P1CD1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DTA24_RS21890 Protein ID WP_002892050.1
Coordinates 4410913..4411131 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1F2MBN7
Locus tag DTA24_RS21885 Protein ID WP_008805436.1
Coordinates 4410512..4410886 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTA24_RS21870 4405667..4406860 + 1194 WP_008805438.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DTA24_RS21875 4406883..4410029 + 3147 WP_008805437.1 multidrug efflux RND transporter permease subunit -
DTA24_RS21885 4410512..4410886 + 375 WP_008805436.1 Hha toxicity modulator TomB Antitoxin
DTA24_RS21890 4410913..4411131 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DTA24_RS21895 4411290..4411856 + 567 WP_008805435.1 maltose O-acetyltransferase -
DTA24_RS21900 4411984..4412454 + 471 WP_008805434.1 YlaC family protein -
DTA24_RS21905 4412423..4413880 - 1458 WP_022066287.1 PLP-dependent aminotransferase family protein -
DTA24_RS21910 4413981..4414679 + 699 WP_016160391.1 GNAT family N-acetyltransferase -
DTA24_RS21915 4414676..4414816 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DTA24_RS21920 4414816..4415079 - 264 WP_008805431.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T113922 WP_002892050.1 NZ_CP033631:4410913-4411131 [Klebsiella sp. P1CD1]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T113922 NZ_CP033631:4410913-4411131 [Klebsiella sp. P1CD1]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14384.06 Da        Isoelectric Point: 4.8989

>AT113922 WP_008805436.1 NZ_CP033631:4410512-4410886 [Klebsiella sp. P1CD1]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYTEDNKLVAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT113922 NZ_CP033631:4410512-4410886 [Klebsiella sp. P1CD1]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACTTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MBN7

References