Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1931387..1931977 Replicon chromosome
Accession NZ_CP033631
Organism Klebsiella sp. P1CD1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag DTA24_RS09720 Protein ID WP_039104087.1
Coordinates 1931645..1931977 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DTA24_RS09715 Protein ID WP_039104089.1
Coordinates 1931387..1931644 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTA24_RS09690 1926996..1927571 + 576 WP_032733307.1 hypothetical protein -
DTA24_RS09695 1927749..1928585 + 837 WP_008804155.1 alpha/beta hydrolase -
DTA24_RS09700 1928791..1929762 + 972 WP_008804156.1 sensor domain-containing diguanylate cyclase -
DTA24_RS09705 1929759..1930859 - 1101 WP_064160538.1 phosphotransferase -
DTA24_RS09715 1931387..1931644 + 258 WP_039104089.1 antitoxin Antitoxin
DTA24_RS09720 1931645..1931977 + 333 WP_039104087.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DTA24_RS09730 1932300..1933736 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
DTA24_RS09740 1934109..1935563 - 1455 WP_008804170.1 AMP nucleosidase -
DTA24_RS09745 1935694..1935939 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11895.77 Da        Isoelectric Point: 10.1839

>T113911 WP_039104087.1 NZ_CP033631:1931645-1931977 [Klebsiella sp. P1CD1]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAIINEVLARLDAILS

Download         Length: 333 bp

>T113911 NZ_CP033631:1931645-1931977 [Klebsiella sp. P1CD1]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCATTATCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9432.97 Da        Isoelectric Point: 4.4915

>AT113911 WP_039104089.1 NZ_CP033631:1931387-1931644 [Klebsiella sp. P1CD1]
MYKTRLKKVGGSIMLAVPPAVLKALELSIDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT113911 NZ_CP033631:1931387-1931644 [Klebsiella sp. P1CD1]
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGATAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References