Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 334671..335302 Replicon chromosome
Accession NZ_CP033631
Organism Klebsiella sp. P1CD1

Toxin (Protein)


Gene name hicA Uniprot ID A0A2V3KJT3
Locus tag DTA24_RS01560 Protein ID WP_044650325.1
Coordinates 334671..334946 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID R4YIG2
Locus tag DTA24_RS01565 Protein ID WP_004181489.1
Coordinates 334943..335302 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTA24_RS01540 329907..330242 + 336 WP_002921203.1 universal stress protein UspB -
DTA24_RS01545 330302..331798 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
DTA24_RS01550 332028..333221 + 1194 WP_082227781.1 NAD(P)/FAD-dependent oxidoreductase -
DTA24_RS01555 333261..334274 - 1014 WP_012540371.1 magnesium transporter -
DTA24_RS01560 334671..334946 + 276 WP_044650325.1 type II toxin-antitoxin system HicA family toxin Toxin
DTA24_RS01565 334943..335302 + 360 WP_004181489.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DTA24_RS01570 335330..335731 - 402 WP_004181488.1 nickel-responsive transcriptional regulator NikR -
DTA24_RS01575 335719..336510 - 792 WP_012540373.1 nickel import ATP-binding protein NikE -
DTA24_RS01580 336507..337271 - 765 WP_048272087.1 nickel import ATP-binding protein NikD -
DTA24_RS01585 337271..338104 - 834 WP_012967107.1 nickel ABC transporter permease subunit NikC -
DTA24_RS01590 338101..339045 - 945 WP_016161924.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10279.91 Da        Isoelectric Point: 10.3165

>T113907 WP_044650325.1 NZ_CP033631:334671-334946 [Klebsiella sp. P1CD1]
MEQQVLSLRNKQRHTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T113907 NZ_CP033631:334671-334946 [Klebsiella sp. P1CD1]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAATCCCTGTGCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13313.02 Da        Isoelectric Point: 4.4605

>AT113907 WP_004181489.1 NZ_CP033631:334943-335302 [Klebsiella sp. P1CD1]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT113907 NZ_CP033631:334943-335302 [Klebsiella sp. P1CD1]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGCCAGCCTGCCGTTATCAATTACGTGCCTGAGCTCAATGC
ATTCCGCGGTAAGTTCCTTGGATTATCAGGATATTGCGATTTTGTTTCCGATAGTATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAGTATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGATGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGCGAGCGTCTTAGCTCCGCCGCTGCGGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KJT3

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2M5Q1

References