Detailed information of TA system TA113900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4690736..4691271
• Replicon: chromosome
• Accession: NZ_CP033623
• Organism: Serratia marcescens strain N10A28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EFZ62_RS22200
• Protein ID: WP_159318805.1
• Coordinates: 4690996..4691271 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5C7DDR0
• Locus tag: EFZ62_RS22195
• Protein ID: WP_041037283.1
• Coordinates: 4690736..4690996 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFZ62_RS22175	4686056..4686706	+	651	WP_049202570.1	DcrB-related protein	-
EFZ62_RS22180	4686747..4687352	+	606	WP_060424313.1	glutathione S-transferase	-
EFZ62_RS22185	4687421..4688815	+	1395	WP_159318803.1	L-seryl-tRNA(Sec) selenium transferase	-
EFZ62_RS22190	4688812..4690653	+	1842	WP_159318804.1	selenocysteine-specific translation elongation factor	-
EFZ62_RS22195	4690736..4690996	+	261	WP_041037283.1	ribbon-helix-helix domain-containing protein	Antitoxin
EFZ62_RS22200	4690996..4691271	+	276	WP_159318805.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EFZ62_RS22205	4691283..4692194	-	912	WP_100396607.1	LysR family transcriptional regulator	-
EFZ62_RS22210	4692316..4692942	+	627	WP_159318806.1	LysE family translocator	-
EFZ62_RS22215	4692996..4694243	-	1248	WP_159318807.1	MFS transporter	-
EFZ62_RS22220	4694461..4695453	+	993	WP_159318808.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10576.35 Da
• Isoelectric Point: 10.3377

>T113900 WP_159318805.1 NZ_CP033623:4690996-4691271 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKVLVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPAAIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T113900 NZ_CP033623:4690996-4691271 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGTTTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCTTGGGTGAAAGGTTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGCTATGAGATACGTTACCAGGTGCAGCCGGCAGCGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9653.95 Da
• Isoelectric Point: 4.5084

>AT113900 WP_041037283.1 NZ_CP033623:4690736-4690996 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Nucleotide

• Length: 261 bp

>AT113900 NZ_CP033623:4690736-4690996 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DDR0