Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4299255..4299991 Replicon chromosome
Accession NZ_CP033623
Organism Serratia marcescens strain N10A28

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7DEM5
Locus tag EFZ62_RS20440 Protein ID WP_015379310.1
Coordinates 4299512..4299991 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7DAD3
Locus tag EFZ62_RS20435 Protein ID WP_015379309.1
Coordinates 4299255..4299515 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFZ62_RS20415 4295326..4296006 + 681 WP_025304546.1 GMP/IMP nucleotidase -
EFZ62_RS20420 4296003..4296410 + 408 WP_015379306.1 ribosome-associated heat shock protein Hsp15 -
EFZ62_RS20425 4296436..4297314 + 879 WP_015379307.1 Hsp33 family molecular chaperone HslO -
EFZ62_RS20430 4297509..4299128 + 1620 WP_015379308.1 phosphoenolpyruvate carboxykinase (ATP) -
EFZ62_RS20435 4299255..4299515 + 261 WP_015379309.1 plasmid stability-like protein Antitoxin
EFZ62_RS20440 4299512..4299991 + 480 WP_015379310.1 type II toxin-antitoxin system VapC family toxin Toxin
EFZ62_RS20445 4300026..4301396 - 1371 WP_038881686.1 two-component system sensor histidine kinase EnvZ -
EFZ62_RS20450 4301393..4302112 - 720 WP_004709363.1 two-component system response regulator OmpR -
EFZ62_RS20455 4302370..4302675 - 306 WP_049202813.1 chaperone-modulator protein CbpM -
EFZ62_RS20460 4302681..4303643 - 963 WP_060424513.1 curved DNA-binding protein -
EFZ62_RS20465 4303874..4304347 + 474 WP_038878177.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17998.63 Da        Isoelectric Point: 5.9070

>T113898 WP_015379310.1 NZ_CP033623:4299512-4299991 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGVSMPDTQIAATCLHYGAALATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Download         Length: 480 bp

>T113898 NZ_CP033623:4299512-4299991 [Serratia marcescens]
ATGATTGTGCTGGATACCAACGTCGTTTCGGAATTGCTGCGGCCGGCGCCTCACTACAATGTATTGCGCTGGTTAGATGA
GCAGGATACGTATCGGTTCTATTTGAGCGCCATCGTGGTTGCGGAGCTGTATACGGGCATCGCCTGCATGCCTCACGGCA
AGAAACAGCTCGAACTGCAAACTAACCTCGGCGACATGCTGCAGGAAGAGTTTTCAGACAGAATCTTACCCTTTGACGTC
GGCTGTGCAATGCAGCATGCGGAATTAATGGGCGCCAATCGCCGCCGAGGCATTGGCGTCAGCATGCCGGATACCCAAAT
CGCCGCCACCTGCCTGCATTACGGTGCCGCCCTGGCCACCCGCAACACCAAAGACTTCCTCCACTGCGGCATCGAGTTAA
TCGATCCGTGGCAGGCGCCGACCGGCCGTCGGTTGCATGAGGATGCGGCGGAATACTACGTGATGAGCAGGAAGTCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9907.29 Da        Isoelectric Point: 5.1898

>AT113898 WP_015379309.1 NZ_CP033623:4299255-4299515 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Download         Length: 261 bp

>AT113898 NZ_CP033623:4299255-4299515 [Serratia marcescens]
ATGGCTACTATCACCGTCAGAAATCTGGACGACGAAATCAAAGAGCTGCTGCGTATTTCAGCGGCGAAAAACGGCCATTC
CATGGAAGAGGAAGCGCGCATGATCCTGAAACAGGCGCTGGTGAAAAAACCGCCGCGCTATGGGTTAGGAACACGCATGC
ATCAGTACTTCGCCGAATTCGGCGGCGTTGAGTTGGAGATCCCCCCACGTGATGAAGCCCCTCATCGTATTGTCAACTTT
GATGAAGACGATGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7DEM5

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DAD3

References