Detailed information of TA system TA113896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 3827472..3827944
• Replicon: chromosome
• Accession: NZ_CP033623
• Organism: Serratia marcescens strain N10A28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: EFZ62_RS18235
• Protein ID: WP_049208401.1
• Coordinates: 3827472..3827747 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EFZ62_RS18240
• Protein ID: WP_159318617.1
• Coordinates: 3827753..3827944 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFZ62_RS18210	3822792..3824072	-	1281	WP_159318616.1	polysaccharide deacetylase family protein	-
EFZ62_RS18215	3824250..3825020	-	771	WP_004937535.1	ABC transporter permease	-
EFZ62_RS18220	3825017..3825940	-	924	WP_033644695.1	ABC transporter ATP-binding protein	-
EFZ62_RS18225	3826151..3826807	+	657	WP_049200096.1	carbonate dehydratase	-
EFZ62_RS18230	3826845..3827381	-	537	WP_048234659.1	hypoxanthine phosphoribosyltransferase	-
EFZ62_RS18235	3827472..3827747	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EFZ62_RS18240	3827753..3827944	-	192	WP_159318617.1	stability determinant	Antitoxin
EFZ62_RS18245	3828050..3829750	-	1701	WP_159318620.1	multicopper oxidase CueO	-
EFZ62_RS18250	3829969..3830316	+	348	WP_004937515.1	YacC family pilotin-like protein	-
EFZ62_RS18255	3830440..3831303	+	864	WP_102985227.1	polyamine aminopropyltransferase	-
EFZ62_RS18260	3831331..3832125	+	795	WP_049200100.1	adenosylmethionine decarboxylase	-
EFZ62_RS18265	3832158..3832520	-	363	WP_004937507.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T113896 WP_049208401.1 NZ_CP033623:c3827747-3827472 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T113896 NZ_CP033623:c3827747-3827472 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCAGAGGCTTTGTTGCAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCAGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7119.87 Da
• Isoelectric Point: 5.0053

>AT113896 WP_159318617.1 NZ_CP033623:c3827944-3827753 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDSWFRSTVESSINSDSPRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT113896 NZ_CP033623:c3827944-3827753 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATAGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAATAGCGACTCCCCCCGTATTCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCAAAAGCCAAAAGAAAATCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D428