Detailed information of TA system TA113895

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3716086..3716755
• Replicon: chromosome
• Accession: NZ_CP033623
• Organism: Serratia marcescens strain N10A28

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EFZ62_RS17715
• Protein ID: WP_060422869.1
• Coordinates: 3716086..3716508 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: EFZ62_RS17720
• Protein ID: WP_019455657.1
• Coordinates: 3716489..3716755 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFZ62_RS17695	3711976..3712494	+	519	WP_038871234.1	flavodoxin FldB	-
EFZ62_RS17700	3712531..3713895	-	1365	WP_070913821.1	cell envelope integrity protein CreD	-
EFZ62_RS17705	3713976..3715394	-	1419	WP_087763650.1	two-component system sensor histidine kinase CreC	-
EFZ62_RS17710	3715391..3716086	-	696	WP_033644777.1	two-component system response regulator CreB	-
EFZ62_RS17715	3716086..3716508	-	423	WP_060422869.1	protein YgfX	Toxin
EFZ62_RS17720	3716489..3716755	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
EFZ62_RS17725	3717076..3718068	+	993	WP_060422867.1	tRNA-modifying protein YgfZ	-
EFZ62_RS17730	3718107..3718604	-	498	WP_070913823.1	DUF2165 domain-containing protein	-
EFZ62_RS17735	3718755..3719429	-	675	WP_038871224.1	hemolysin III family protein	-
EFZ62_RS17740	3719613..3720221	+	609	WP_025304127.1	HD domain-containing protein	-
EFZ62_RS17745	3720254..3721180	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16438.50 Da
• Isoelectric Point: 10.8114

>T113895 WP_060422869.1 NZ_CP033623:c3716508-3716086 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T113895 NZ_CP033623:c3716508-3716086 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTGGGCCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGAGGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT113895 WP_019455657.1 NZ_CP033623:c3716755-3716489 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT113895 NZ_CP033623:c3716755-3716489 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04