Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2497067..2497698 Replicon chromosome
Accession NZ_CP033623
Organism Serratia marcescens strain N10A28

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag EFZ62_RS12030 Protein ID WP_033640020.1
Coordinates 2497067..2497465 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag EFZ62_RS12035 Protein ID WP_041035628.1
Coordinates 2497465..2497698 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFZ62_RS12005 2492641..2493012 + 372 WP_033647787.1 type II toxin-antitoxin system RelE/ParE family toxin -
EFZ62_RS12010 2493009..2493311 + 303 WP_038876832.1 DNA-binding transcriptional regulator -
EFZ62_RS12015 2493314..2493718 - 405 WP_060420791.1 flagellar protein FlhE -
EFZ62_RS12020 2493718..2495796 - 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
EFZ62_RS12025 2495789..2496940 - 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
EFZ62_RS12030 2497067..2497465 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
EFZ62_RS12035 2497465..2497698 - 234 WP_041035628.1 antitoxin Antitoxin
EFZ62_RS12040 2497824..2498468 - 645 WP_004934858.1 protein phosphatase CheZ -
EFZ62_RS12045 2498479..2498868 - 390 WP_060420785.1 chemotaxis response regulator CheY -
EFZ62_RS12050 2498971..2500020 - 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
EFZ62_RS12055 2500020..2500892 - 873 WP_159318131.1 protein-glutamate O-methyltransferase CheR -
EFZ62_RS12060 2500930..2502546 - 1617 WP_047730456.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T113892 WP_033640020.1 NZ_CP033623:c2497465-2497067 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T113892 NZ_CP033623:c2497465-2497067 [Serratia marcescens]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGCCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCAGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGGTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT113892 WP_041035628.1 NZ_CP033623:c2497698-2497465 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT113892 NZ_CP033623:c2497698-2497465 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGATAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References