Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 551292..552058 Replicon chromosome
Accession NZ_CP033623
Organism Serratia marcescens strain N10A28

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag EFZ62_RS02620 Protein ID WP_141958300.1
Coordinates 551690..552058 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EFZ62_RS02615 Protein ID WP_141958298.1
Coordinates 551292..551630 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFZ62_RS02590 546641..547117 + 477 WP_141958291.1 hypothetical protein -
EFZ62_RS02595 547648..548808 + 1161 WP_141958293.1 putative lipopolysaccharide heptosyltransferase III -
EFZ62_RS02600 548861..550105 + 1245 WP_141958294.1 O-antigen ligase family protein -
EFZ62_RS02605 550300..550758 + 459 WP_141958296.1 antirestriction protein -
EFZ62_RS02610 550784..551263 + 480 WP_141960602.1 DNA repair protein RadC -
EFZ62_RS02615 551292..551630 + 339 WP_141958298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EFZ62_RS02620 551690..552058 + 369 WP_141958300.1 TA system toxin CbtA family protein Toxin
EFZ62_RS02625 552055..552384 + 330 WP_141958302.1 hypothetical protein -
EFZ62_RS02630 552483..552656 + 174 WP_159317730.1 hypothetical protein -
EFZ62_RS02635 552967..553293 + 327 WP_048322373.1 gamma-glutamylcyclotransferase -
EFZ62_RS25000 553402..553545 + 144 WP_016928795.1 hypothetical protein -
EFZ62_RS02640 553671..555212 + 1542 WP_102984151.1 glycosyltransferase family 39 protein -
EFZ62_RS02645 555286..556053 - 768 WP_197779368.1 serine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 508023..578033 70010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(9-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13326.30 Da        Isoelectric Point: 8.5167

>T113883 WP_141958300.1 NZ_CP033623:551690-552058 [Serratia marcescens]
MRTVPASPTQAAQPCPSPITVWQSLLTYLLTQHYGLTLNDTAFSDDAVIQAHLDDGISLADALNAMVEKFDLVRIDRRGF
SGLAQSPLVTAIDILRARRACGLMTRAGYREVTRTIQGGKRP

Download         Length: 369 bp

>T113883 NZ_CP033623:551690-552058 [Serratia marcescens]
ATGCGAACAGTACCCGCGTCACCCACACAGGCGGCTCAGCCTTGCCCATCTCCCATAACTGTCTGGCAATCCTTGCTCAC
CTACCTGCTGACGCAGCACTACGGCCTGACGCTCAACGACACCGCATTCAGCGACGATGCCGTGATACAGGCACACCTCG
ATGACGGTATCTCCCTCGCGGATGCGCTGAATGCCATGGTGGAAAAGTTTGATCTGGTGCGTATTGACCGCCGGGGCTTC
AGCGGTCTGGCGCAATCGCCCCTCGTGACTGCCATTGACATCTTGCGCGCCCGCAGGGCCTGCGGCCTGATGACGCGAGC
CGGTTACCGGGAGGTCACACGAACGATTCAGGGAGGCAAACGCCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12684.34 Da        Isoelectric Point: 6.6336

>AT113883 WP_141958298.1 NZ_CP033623:551292-551630 [Serratia marcescens]
MTSTKNVPSWGLKRNVTPQFGARLVQEGERLHFLADRADISGIFSDAQRYDLEKAFPQFINHLELMLLSGELNPRHQHCV
TLYSHGLTCEADSLGSYGYVYLSIYPTPEAPR

Download         Length: 339 bp

>AT113883 NZ_CP033623:551292-551630 [Serratia marcescens]
ATGACATCGACCAAGAACGTTCCATCCTGGGGACTGAAACGCAACGTCACACCGCAGTTTGGCGCCCGTTTGGTACAAGA
GGGGGAACGACTGCATTTTCTGGCCGACCGTGCTGACATCAGCGGAATTTTCAGCGACGCACAGCGCTATGATTTGGAGA
AGGCTTTTCCGCAGTTCATCAACCACCTGGAATTGATGCTGCTCTCCGGTGAGCTCAATCCGCGTCATCAGCACTGTGTC
ACGCTGTATAGCCATGGCCTGACCTGCGAAGCCGACAGCTTGGGCTCATACGGCTACGTTTATCTCTCGATTTATCCGAC
ACCTGAAGCGCCCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References