113881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4656141..4657729 Replicon chromosome
Accession NZ_CP033622
Organism Dickeya zeae strain CE1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DWG24_RS20840 Protein ID WP_168363923.1
Coordinates 4656141..4657460 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DWG24_RS20845 Protein ID WP_168364151.1
Coordinates 4657460..4657729 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWG24_RS20820 4651312..4651569 + 258 WP_012886807.1 membrane protein insertion efficiency factor YidD -
DWG24_RS20825 4651572..4653203 + 1632 WP_168363922.1 membrane protein insertase YidC -
DWG24_RS20830 4653320..4654684 + 1365 WP_012886805.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
DWG24_RS20835 4654723..4656045 - 1323 WP_102800868.1 IS4 family transposase -
DWG24_RS20840 4656141..4657460 - 1320 WP_168363923.1 type II toxin-antitoxin system HipA family toxin Toxin
DWG24_RS20845 4657460..4657729 - 270 WP_168364151.1 helix-turn-helix domain-containing protein Antitoxin
DWG24_RS20850 4657906..4658883 - 978 WP_168363924.1 helix-turn-helix domain-containing protein -
DWG24_RS20855 4658927..4659700 - 774 WP_168363925.1 MBL fold metallo-hydrolase -
DWG24_RS20860 4660019..4661107 + 1089 WP_168363926.1 4-hydroxyphenylpyruvate dioxygenase -
DWG24_RS20865 4661221..4661607 - 387 WP_168363927.1 helix-turn-helix transcriptional regulator -
DWG24_RS20870 4661750..4662361 + 612 WP_168363928.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4654723..4656045 1322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49375.62 Da        Isoelectric Point: 6.9261

>T113881 WP_168363923.1 NZ_CP033622:c4657460-4656141 [Dickeya zeae]
MAALDVYMNGYRVGILTKTGSGAHHFSYDVNWLGLSGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGRDSVGALQLIPASTPTNNIKQIEYKTLSEQQLENILSGYLVDAPLGMIDTEDDFRISIAGAQEKTA
LLYRDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAREFGLPVPHCFMLNAGKIKALAVERFDRK
YASDGSWVMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKVQVLFWLLAATDGHAKNFSLFI
EPEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLASSKGKKYAIEQIFPRHFFQTAQVVGFARESMESILTEFAQSM
DTIVMKIRNQLPASFPASIRDAILEGMQARAGRLMTGWE

Download         Length: 1320 bp

>T113881 NZ_CP033622:c4657460-4656141 [Dickeya zeae]
ATGGCTGCGCTCGATGTCTACATGAACGGTTATCGGGTGGGGATATTGACCAAAACAGGTAGTGGGGCACATCATTTTTC
CTATGATGTGAACTGGCTTGGGTTGTCGGGAAGTCGCCCTATCTCACTCTCTATGCCACTACGTCATCAGCCCTATCAAG
GTGATGAAGTTTATAACTTCTTCGACAATTTGTTGCCGGATAATCCGGACATCAGAAGACGAATTGTTGCCAGGCATCAC
GCTGACTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCGAGACAGTGTTGGGGCGTTGCAATTGATACCGGCGAG
TACACCAACTAACAATATAAAACAGATTGAATACAAAACATTATCTGAGCAGCAGCTTGAAAACATACTGTCGGGATATC
TGGTTGATGCGCCGCTGGGGATGATTGATACAGAAGATGATTTTCGTATCTCTATTGCTGGCGCACAGGAAAAGACGGCT
CTGCTTTATCGGGATAATCACTGGTGCCTGCCCTTCAATACCACACCCACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTGATTGCCAGGGAGT
TTGGGCTACCGGTGCCACACTGTTTTATGCTCAACGCTGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGTAAA
TATGCCTCGGATGGCAGTTGGGTTATGCGATTGCCACAGGAGGATTTTTGTCAGGTATTAAACGTGCCTTCCGCGCTGAA
ATATGAAAATCATGGTGGGCCCGGTATTTCCGCCATTATGTCGTATCTATTAGGCGCTGTTGACCCACAAAGGGATCGCT
ATAGTTTTATGAAGGTTCAGGTGCTGTTCTGGCTATTGGCAGCAACAGATGGTCATGCGAAGAATTTTTCCTTGTTTATT
GAGCCTGAGGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGTGGGCGGGGAATTGA
TCGCAGAGAGGCAAAACTGGCGATGGGGCTGGCTAGCTCAAAAGGCAAGAAATACGCGATTGAGCAGATCTTTCCACGTC
ACTTTTTCCAAACGGCGCAGGTAGTTGGGTTTGCCAGAGAATCAATGGAGAGCATTCTGACGGAATTTGCACAGTCGATG
GATACGATTGTGATGAAAATTAGGAACCAACTACCTGCGAGTTTTCCTGCATCTATTCGCGATGCAATTCTCGAAGGCAT
GCAGGCAAGAGCGGGGCGATTAATGACCGGGTGGGAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10008.27 Da        Isoelectric Point: 8.5848

>AT113881 WP_168364151.1 NZ_CP033622:c4657729-4657460 [Dickeya zeae]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTSRNMDAANNEASV
AESSWKEEW

Download         Length: 270 bp

>AT113881 NZ_CP033622:c4657729-4657460 [Dickeya zeae]
ATGAAGGTCACCAACAGCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGTCAGGATACGGTATCCAGCTTCGAACAGCATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTAAATTTAGAACTTACGGTTACCTCCAGGAATATGGATGCCGCCAATAACGAGGCCTCTGTT
GCAGAATCGTCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References