Detailed information of TA system TA113880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4510255..4510865
• Replicon: chromosome
• Accession: NZ_CP033622
• Organism: Dickeya zeae strain CE1

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: DWG24_RS20235
• Protein ID: WP_038902958.1
• Coordinates: 4510473..4510865 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: DWG24_RS20230
• Protein ID: WP_016941532.1
• Coordinates: 4510255..4510476 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWG24_RS20205	4506676..4508355	+	1680	WP_168363835.1	retron Ec67 family RNA-directed DNA polymerase/endonuclease	-
DWG24_RS20210	4508616..4508861	-	246	WP_168363836.1	hypothetical protein	-
DWG24_RS20215	4509006..4509338	+	333	WP_168364142.1	helix-turn-helix domain-containing protein	-
DWG24_RS20220	4509346..4509603	-	258	WP_027713493.1	helix-turn-helix domain-containing protein	-
DWG24_RS20225	4509702..4510022	+	321	WP_168363837.1	helix-turn-helix domain-containing protein	-
DWG24_RS20230	4510255..4510476	+	222	WP_016941532.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DWG24_RS20235	4510473..4510865	+	393	WP_038902958.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
DWG24_RS20240	4511275..4511523	-	249	WP_168364143.1	DUF1471 domain-containing protein	-
DWG24_RS20245	4512100..4512738	+	639	WP_168363838.1	acyl-homoserine-lactone synthase	-
DWG24_RS20250	4512704..4513456	-	753	WP_168363839.1	LuxR family transcriptional regulator	-
DWG24_RS20255	4514100..4514411	+	312	WP_168363840.1	hypothetical protein	-
DWG24_RS20260	4514404..4515744	+	1341	WP_168363841.1	type III PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4494744..4510865	16121

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (2-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14716.73 Da
• Isoelectric Point: 6.2279

>T113880 WP_038902958.1 NZ_CP033622:4510473-4510865 [Dickeya zeae]
MIWVSAQEVIAFHDRILQRLPGVAGMPDPGRAEALIYRVQNRTHYEGVTDIFELAATYWVAIARGHIFNDGNKRTAFFVA
ITFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAQSLRDLVDNLIPTR

Nucleotide

• Length: 393 bp

>T113880 NZ_CP033622:4510473-4510865 [Dickeya zeae]
ATGATATGGGTCAGCGCACAGGAAGTTATCGCTTTCCATGACCGTATTTTACAACGACTTCCCGGCGTTGCTGGCATGCC
CGACCCGGGTAGAGCCGAAGCACTCATCTATCGGGTACAAAACCGCACGCACTACGAAGGCGTTACAGATATTTTTGAGC
TCGCCGCTACCTACTGGGTTGCTATTGCTCGTGGGCACATTTTTAATGATGGCAATAAACGCACGGCGTTCTTTGTGGCT
ATAACGTTTCTCTACCGCAATGGCATCCGCATTCGTGATACCGACAATACGCTGGAGAACTTAACGGTAGAAGCAGCGAC
AGGCGAGAAAACCGTTGACCAGTTAGCACAGTCTTTGCGAGATTTAGTAGATAACCTTATCCCAACTCGCTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8008.89 Da
• Isoelectric Point: 5.6233

>AT113880 WP_016941532.1 NZ_CP033622:4510255-4510476 [Dickeya zeae]
MRTFTSTQARANISAVLDAATQGEPVEITRRDGSSAVVISKADFEAYQNAKLDAEFDVIMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT113880 NZ_CP033622:4510255-4510476 [Dickeya zeae]
ATGCGTACATTCACCTCAACTCAAGCCCGTGCCAATATCTCAGCAGTATTGGATGCCGCTACTCAAGGTGAACCGGTTGA
AATCACTCGTAGAGATGGCAGTTCAGCGGTGGTTATCAGCAAAGCTGACTTCGAGGCATACCAAAACGCTAAACTCGATG
CCGAGTTTGATGTGATTATGCAGCGTCATGGACACACCGTAGAGGCACTGACAAACCGATGA