113877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3500630..3501255 Replicon chromosome
Accession NZ_CP033622
Organism Dickeya zeae strain CE1

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DWG24_RS15505 Protein ID WP_009114000.1
Coordinates 3501052..3501255 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag DWG24_RS15500 Protein ID WP_012883774.1
Coordinates 3500630..3500998 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWG24_RS15485 3496390..3499536 + 3147 WP_168363200.1 efflux RND transporter permease subunit -
DWG24_RS15490 3499710..3499961 + 252 WP_168363201.1 type B 50S ribosomal protein L31 -
DWG24_RS15495 3499977..3500120 + 144 WP_012770724.1 type B 50S ribosomal protein L36 -
DWG24_RS15500 3500630..3500998 + 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
DWG24_RS15505 3501052..3501255 + 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DWG24_RS15515 3501806..3502132 + 327 WP_012883773.1 MGMT family protein -
DWG24_RS15520 3502173..3502754 - 582 WP_168363202.1 YbaY family lipoprotein -
DWG24_RS15525 3502972..3503835 + 864 WP_168363203.1 acyl-CoA thioesterase II -
DWG24_RS15530 3503959..3505251 - 1293 WP_168363204.1 ammonium transporter AmtB -
DWG24_RS15535 3505295..3505633 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T113877 WP_009114000.1 NZ_CP033622:3501052-3501255 [Dickeya zeae]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T113877 NZ_CP033622:3501052-3501255 [Dickeya zeae]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCTGCAGACCATCGTCTGGCTGAGCTAACGATGAATAAAC
TTTACGACAAAGTGCCAACTGCCGTGTGGAAATACGTTCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT113877 WP_012883774.1 NZ_CP033622:3500630-3500998 [Dickeya zeae]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT113877 NZ_CP033622:3500630-3500998 [Dickeya zeae]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
AACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGTTGTGTGAGCGGGTTGAAAAATACCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATTCAGAGTTGCAGAAATGGAAAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCGTCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References