Detailed information of TA system TA113865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1616008..1616620
• Replicon: chromosome
• Accession: NZ_CP033621
• Organism: Streptococcus pyogenes strain M75

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q1JEY4
• Locus tag: EGC57_RS08375
• Protein ID: WP_020905490.1
• Coordinates: 1616285..1616620 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: EGC57_RS08370
• Protein ID: WP_002988079.1
• Coordinates: 1616008..1616295 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGC57_RS08345	1611189..1612172	-	984	WP_020905487.1	tagatose-bisphosphate aldolase	-
EGC57_RS08350	1612176..1613105	-	930	WP_076639463.1	tagatose-6-phosphate kinase	-
EGC57_RS08355	1613151..1613666	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
EGC57_RS08360	1613701..1614129	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
EGC57_RS08365	1614574..1615347	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
EGC57_RS08370	1616008..1616295	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
EGC57_RS08375	1616285..1616620	+	336	WP_020905490.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGC57_RS09640	1616772..1617242	+	471	Protein_1552	tyrosine-type recombinase/integrase family protein	-
EGC57_RS09645	1617604..1617705	+	102	WP_180372495.1	hypothetical protein	-
EGC57_RS08390	1617873..1618265	-	393	WP_002982716.1	30S ribosomal protein S9	-
EGC57_RS08395	1618286..1618732	-	447	WP_002982710.1	50S ribosomal protein L13	-
EGC57_RS08400	1618950..1619156	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
EGC57_RS08405	1619153..1619851	-	699	WP_161237464.1	hypothetical protein	-
EGC57_RS08410	1619987..1620847	-	861	WP_002982687.1	DegV family protein	-
EGC57_RS08415	1620944..1621462	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13147.98 Da
• Isoelectric Point: 4.9405

>T113865 WP_020905490.1 NZ_CP033621:1616285-1616620 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T113865 NZ_CP033621:1616285-1616620 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCTTTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT113865 WP_002988079.1 NZ_CP033621:1616008-1616295 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT113865 NZ_CP033621:1616008-1616295 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: Q1JEY4

Antitoxin

• AlphaFold DB: A0A4U7GX94