Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 50226..50791 Replicon chromosome
Accession NZ_CP033615
Organism Leptospira kmetyi strain LS 001/16

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EFP84_RS18745 Protein ID WP_118965858.1
Coordinates 50226..50549 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EFP84_RS18750 Protein ID WP_123180409.1
Coordinates 50543..50791 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFP84_RS18715 45302..46936 - 1635 WP_123180403.1 DUF262 domain-containing protein -
EFP84_RS18720 47165..47665 - 501 WP_123180404.1 hypothetical protein -
EFP84_RS18725 47669..47959 - 291 WP_164477087.1 hypothetical protein -
EFP84_RS18730 48106..48396 - 291 WP_123180406.1 hypothetical protein -
EFP84_RS18735 48612..49376 - 765 WP_123180407.1 hypothetical protein -
EFP84_RS18740 49366..49944 - 579 WP_123180408.1 hypothetical protein -
EFP84_RS18745 50226..50549 - 324 WP_118965858.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EFP84_RS18750 50543..50791 - 249 WP_123180409.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EFP84_RS18760 51406..52182 - 777 WP_123180410.1 hypothetical protein -
EFP84_RS18765 52404..53774 - 1371 WP_164477088.1 hypothetical protein -
EFP84_RS18775 54010..55449 - 1440 WP_123180413.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12212.64 Da        Isoelectric Point: 10.5161

>T113863 WP_118965858.1 NZ_CP033615:c50549-50226 [Leptospira kmetyi]
MVISQYEVYLINLDPTVGHEIKKSRPCVIISPNEMNKTIGTIIIAPMTTKSRSYPTRVELTFQGKKGWIVLDQIRTVDKT
RLAKKLGKIDPKTVNKMKLIIKEMLVD

Download         Length: 324 bp

>T113863 NZ_CP033615:c50549-50226 [Leptospira kmetyi]
ATGGTGATTTCTCAATACGAAGTATATTTGATAAATTTGGATCCAACGGTCGGACATGAGATAAAGAAATCAAGACCTTG
CGTAATAATCTCACCTAACGAAATGAATAAAACTATTGGGACAATCATTATTGCACCAATGACTACTAAATCACGATCTT
ATCCAACAAGAGTCGAATTGACATTTCAAGGAAAGAAAGGCTGGATTGTGTTAGATCAAATCCGAACCGTTGATAAAACA
CGTCTGGCAAAAAAGTTAGGAAAAATAGATCCAAAAACAGTTAATAAAATGAAACTGATTATAAAGGAAATGTTGGTTGA
TTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9402.89 Da        Isoelectric Point: 5.1632

>AT113863 WP_123180409.1 NZ_CP033615:c50791-50543 [Leptospira kmetyi]
MKASVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPRDGWEKQFKAMSSNKDDKLLIPDSIDLSDKDW
EW

Download         Length: 249 bp

>AT113863 NZ_CP033615:c50791-50543 [Leptospira kmetyi]
ATGAAGGCTTCAGTTGTAAAAATAGGCAATTCAAAAGGTATTCGAATCCCTAAGGCTGTTTTGGAAGAATGCCATATTGA
AGAAGAAGTAGATTTACTAATCGATAATAATAAACTAATAATTGTTCCTCTAAAATCGAAACCAAGAGACGGGTGGGAAA
AACAATTTAAGGCAATGTCATCTAATAAAGATGATAAATTACTTATTCCAGACTCAATAGATTTATCAGACAAGGATTGG
GAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References