Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 1734120..1734685 Replicon chromosome
Accession NZ_CP033614
Organism Leptospira kmetyi strain LS 001/16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EFP84_RS08175 Protein ID WP_123179469.1
Coordinates 1734120..1734458 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EFP84_RS08180 Protein ID WP_100737552.1
Coordinates 1734455..1734685 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFP84_RS08150 1730207..1730593 - 387 WP_100737549.1 LipL41-expression chaperone Lep -
EFP84_RS08155 1730568..1731641 - 1074 WP_040913038.1 lipoprotein LipL41 -
EFP84_RS08160 1731812..1732333 + 522 WP_010573652.1 hypothetical protein -
EFP84_RS08165 1732330..1733304 + 975 WP_010573651.1 quinolinate synthase NadA -
EFP84_RS08170 1733582..1734067 + 486 WP_123179468.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
EFP84_RS08175 1734120..1734458 - 339 WP_123179469.1 DUF5615 family PIN-like protein Toxin
EFP84_RS08180 1734455..1734685 - 231 WP_100737552.1 DUF433 domain-containing protein Antitoxin
EFP84_RS08185 1734828..1735571 - 744 WP_123179470.1 hypothetical protein -
EFP84_RS08190 1735622..1736662 - 1041 WP_123179471.1 glycoside hydrolase xylanase -
EFP84_RS08195 1736850..1737296 - 447 WP_100737691.1 GNAT family N-acetyltransferase -
EFP84_RS08200 1737387..1737734 + 348 WP_010573646.1 hypothetical protein -
EFP84_RS08205 1737789..1738787 + 999 WP_100737553.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-79)

Antitoxin

Protein of unknown function DUF433

(9-64)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12686.75 Da        Isoelectric Point: 5.1212

>T113862 WP_123179469.1 NZ_CP033614:c1734458-1734120 [Leptospira kmetyi]
MTIWLDAQLSPKLATWISDEMGIKTLSVRELLLSSKTDREIFFQARGQSGVIIMSKDSDFIDLVNQYGPPPKFIWIRSGN
TSNEFIKKTLIKTLPIALDLLQKTESIVEISD

Download         Length: 339 bp

>T113862 NZ_CP033614:c1734458-1734120 [Leptospira kmetyi]
TTGACAATTTGGTTGGATGCACAGCTATCTCCAAAACTTGCCACGTGGATTTCCGACGAAATGGGAATCAAAACCCTAAG
CGTTCGAGAACTCCTTCTTTCCTCAAAAACCGATAGGGAAATATTTTTTCAAGCAAGAGGACAGTCCGGTGTTATCATAA
TGAGTAAGGATAGCGATTTTATTGATTTAGTGAATCAATACGGACCGCCTCCTAAATTTATTTGGATTCGATCCGGAAAT
ACTTCCAATGAGTTTATAAAAAAGACGCTAATCAAAACTCTTCCCATTGCTTTGGATCTTCTTCAGAAAACGGAAAGTAT
AGTGGAAATTTCGGATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8280.73 Da        Isoelectric Point: 5.5917

>AT113862 WP_100737552.1 NZ_CP033614:c1734685-1734455 [Leptospira kmetyi]
MNPNLLQRITVNPGVCGGKPCIRGLRIRVIDVLELFSNGLSHAQILEEMPDLEPDDLKASLLYASMKIDHAVVLAG

Download         Length: 231 bp

>AT113862 NZ_CP033614:c1734685-1734455 [Leptospira kmetyi]
ATGAATCCGAATCTTTTACAAAGAATCACTGTAAATCCCGGAGTATGTGGTGGAAAACCTTGTATTCGAGGGCTTCGTAT
TCGTGTAATCGACGTGCTGGAACTTTTTTCCAATGGATTATCTCATGCTCAGATCTTAGAAGAAATGCCGGATTTAGAGC
CGGATGATCTAAAGGCGAGTTTGCTGTATGCATCCATGAAGATCGATCATGCAGTGGTACTTGCCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References