Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 523418..523989 Replicon chromosome
Accession NZ_CP033604
Organism Aeromonas veronii strain MS-18-37

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag EFI48_RS02480 Protein ID WP_000351248.1
Coordinates 523418..523819 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag EFI48_RS02485 Protein ID WP_001080654.1
Coordinates 523819..523989 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFI48_RS02460 518724..519809 + 1086 WP_164461671.1 AI-2E family transporter YdiK -
EFI48_RS02465 520115..521212 - 1098 WP_123172271.1 ISAs1-like element ISAeme2 family transposase -
EFI48_RS02470 521458..523269 - 1812 WP_123172272.1 DUF4209 domain-containing protein -
EFI48_RS02480 523418..523819 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
EFI48_RS02485 523819..523989 - 171 WP_001080654.1 hypothetical protein Antitoxin
EFI48_RS02490 524483..526384 + 1902 WP_123174106.1 PTS-dependent dihydroxyacetone kinase operon transcriptional regulator DhaR -
EFI48_RS02495 526479..527561 - 1083 WP_123172273.1 glycerol dehydrogenase -
EFI48_RS02500 527693..528409 - 717 WP_123172274.1 HPr family phosphocarrier protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 520115..521212 1097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T113832 WP_000351248.1 NZ_CP033604:c523819-523418 [Aeromonas veronii]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T113832 NZ_CP033604:c523819-523418 [Aeromonas veronii]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAAATTAATGCGTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCAGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGGACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACACAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT113832 WP_001080654.1 NZ_CP033604:c523989-523819 [Aeromonas veronii]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT113832 NZ_CP033604:c523989-523819 [Aeromonas veronii]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAATCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References