Detailed information of TA system TA113828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 47300..47901
• Replicon: chromosome
• Accession: NZ_CP033599
• Organism: Pasteurella multocida strain CQ2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PmCQ2_RS00305
• Protein ID: WP_071523842.1
• Coordinates: 47300..47614 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PmCQ2_RS00310
• Protein ID: WP_102822911.1
• Coordinates: 47611..47901 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PmCQ2_RS11235	43164..43325	-	162	WP_014390707.1	hypothetical protein	-
PmCQ2_RS00270	43339..43575	-	237	WP_016570068.1	hypothetical protein	-
PmCQ2_RS00275	43562..43846	-	285	WP_064775602.1	hypothetical protein	-
PmCQ2_RS00280	43913..44224	+	312	WP_014390710.1	hypothetical protein	-
PmCQ2_RS00285	44286..44921	-	636	WP_156734823.1	Bro-N domain-containing protein	-
PmCQ2_RS00290	45383..45916	-	534	WP_014391102.1	hypothetical protein	-
PmCQ2_RS00295	46004..46267	-	264	WP_014391456.1	hypothetical protein	-
PmCQ2_RS00300	46492..46722	-	231	WP_016533507.1	hypothetical protein	-
PmCQ2_RS00305	47300..47614	+	315	WP_071523842.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PmCQ2_RS00310	47611..47901	+	291	WP_102822911.1	putative addiction module antidote protein	Antitoxin
PmCQ2_RS00315	47927..48364	-	438	WP_078819883.1	hypothetical protein	-
PmCQ2_RS00320	48738..49415	-	678	WP_016569989.1	XRE family transcriptional regulator	-
PmCQ2_RS00325	49539..49736	+	198	WP_014390719.1	helix-turn-helix domain-containing protein	-
PmCQ2_RS00330	49785..50237	+	453	WP_102822910.1	hypothetical protein	-
PmCQ2_RS00335	50490..50750	+	261	WP_016569986.1	Rha family transcriptional regulator	-
PmCQ2_RS00340	50747..51100	+	354	WP_014390722.1	HNH endonuclease	-
PmCQ2_RS00345	51102..52003	+	902	Protein_64	hypothetical protein	-
PmCQ2_RS00350	52003..52692	+	690	WP_064964930.1	replication protein P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	35037..98633	63596

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-89)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-91)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11777.68 Da
• Isoelectric Point: 9.5553

>T113828 WP_071523842.1 NZ_CP033599:47300-47614 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRIYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Nucleotide

• Length: 315 bp

>T113828 NZ_CP033599:47300-47614 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAGTCGTGCTAAAAGTGGTAATTTTGGCGATCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGATTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACGCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10560.20 Da
• Isoelectric Point: 5.7134

>AT113828 WP_102822911.1 NZ_CP033599:47611-47901 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEVLETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Nucleotide

• Length: 291 bp

>AT113828 NZ_CP033599:47611-47901 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCCGCATATTTAAG
TGAAGTTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA