113819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4503043..4504583 Replicon chromosome
Accession NZ_CP033575
Organism Shewanella algae strain KC-Na-R1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EEY24_RS21330 Protein ID WP_123116961.1
Coordinates 4503043..4504344 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EEY24_RS21335 Protein ID WP_123116962.1
Coordinates 4504347..4504583 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEY24_RS21300 4498248..4498523 + 276 WP_045283442.1 hypothetical protein -
EEY24_RS21305 4498575..4499009 + 435 WP_020442396.1 HNH endonuclease -
EEY24_RS21310 4499348..4499695 + 348 WP_025011793.1 hypothetical protein -
EEY24_RS21315 4500125..4501288 + 1164 WP_123116958.1 RNA ligase RtcB family protein -
EEY24_RS21320 4501288..4501923 + 636 WP_123116959.1 peptide chain release factor H -
EEY24_RS21325 4502029..4502982 - 954 WP_164489482.1 sel1 repeat family protein -
EEY24_RS21330 4503043..4504344 - 1302 WP_123116961.1 HipA domain-containing protein Toxin
EEY24_RS21335 4504347..4504583 - 237 WP_123116962.1 helix-turn-helix domain-containing protein Antitoxin
EEY24_RS21340 4505508..4505945 + 438 Protein_3946 hypothetical protein -
EEY24_RS21350 4506571..4507422 + 852 WP_123116963.1 nucleotidyltransferase -
EEY24_RS21355 4507415..4508224 + 810 WP_123116964.1 hypothetical protein -
EEY24_RS21360 4508319..4509581 + 1263 WP_123116965.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48513.27 Da        Isoelectric Point: 4.6439

>T113819 WP_123116961.1 NZ_CP033575:c4504344-4503043 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWQQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEEPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGQHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYVYQLAAFSEDIGLPRALVSNSLTRMATRISQEIDGVIAMLDGLD
NDEQAFVASYKAQLLARCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T113819 NZ_CP033575:c4504344-4503043 [Shewanella algae]
ATGAGTGGAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGAGTTGTCATTCGATCCCGCTAC
TGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCAGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCCGAAAACAGGGGCTTGGATTACCTCATCGAATCT
CTCGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATTGGCTTGGATACTGCCGGTGCCGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTGCGCCTGGAAGAGCCTGAAC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCGAAACTGAATCTGTTCTACAAC
GGTAAGCAATTTGGTTTCGGTGAAGGTGCCTTATCATCGACCCATATCTTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGTCGATAGCCATGAATGTCGCGAATGTTGAGATCCGCCATTTTGGCCAGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAACAGCGGGTGCTGAGAAGGCATATTATCGAT
AGCTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
CGAAGGTGTTAGCCTGCCCAGGCTGTTTGCTCTTGCGGAGCAATGCGCTAATCCGGCGGCGGCCAAACAGGATATGCTGC
AGTGGACGCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATGACACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCTTGTATGAAGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGTCTATCAATTGGCCGCTTTCAGCGAGGATATAGGGTTACCCAGAGCCTTGG
TGAGCAACAGCCTAACCAGAATGGCGACCAGAATAAGCCAAGAAATAGACGGTGTTATCGCAATGCTCGATGGATTGGAT
AACGATGAGCAGGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGGCAAGGTGTGAGCGCTATTTGGATATTGCGCCCCA
AATCAATGAGATGGAACTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8491.01 Da        Isoelectric Point: 9.6887

>AT113819 WP_123116962.1 NZ_CP033575:c4504583-4504347 [Shewanella algae]
MASTLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIRLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT113819 NZ_CP033575:c4504583-4504347 [Shewanella algae]
ATGGCCTCCACATTAACTCCACATTCATTGGGCGCTTTAATTAAGGCCCGTAGAAAAGAAGCGGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAAGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGTTTGGGGATCCGTCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References