Detailed information of TA system TA113818

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3904412..3905054
• Replicon: chromosome
• Accession: NZ_CP033575
• Organism: Shewanella algae strain KC-Na-R1

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: -
• Locus tag: EEY24_RS18665
• Protein ID: WP_123116740.1
• Coordinates: 3904412..3904834 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: EEY24_RS18670
• Protein ID: WP_028779782.1
• Coordinates: 3904815..3905054 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EEY24_RS18640	3899929..3900408	-	480	WP_071238276.1	SoxR reducing system RseC family protein	-
EEY24_RS18645	3900419..3901351	-	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
EEY24_RS18650	3901361..3901981	-	621	WP_123116739.1	anti-sigma factor	-
EEY24_RS18655	3902006..3902584	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
EEY24_RS18660	3902784..3904394	+	1611	WP_025010550.1	L-aspartate oxidase	-
EEY24_RS18665	3904412..3904834	-	423	WP_123116740.1	hypothetical protein	Toxin
EEY24_RS18670	3904815..3905054	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
EEY24_RS18675	3905153..3906061	-	909	WP_025010548.1	transcriptional activator NhaR	-
EEY24_RS18680	3906078..3906446	-	369	WP_096141176.1	hypothetical protein	-
EEY24_RS18685	3906458..3907633	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
EEY24_RS18690	3907750..3908544	-	795	WP_123116741.1	thymidylate synthase	-
EEY24_RS18695	3908544..3909371	-	828	WP_123116742.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16368.93 Da
• Isoelectric Point: 7.5553

>T113818 WP_123116740.1 NZ_CP033575:c3904834-3904412 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSRFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T113818 NZ_CP033575:c3904834-3904412 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCGCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT113818 WP_028779782.1 NZ_CP033575:c3905054-3904815 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT113818 NZ_CP033575:c3905054-3904815 [Shewanella algae]
ATGAGTACCCCCAGGGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1