Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3250917..3251752 | Replicon | chromosome |
| Accession | NZ_CP033510 | ||
| Organism | Shigella flexneri strain 2016AM-0877 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | EEL47_RS16360 | Protein ID | WP_000854726.1 |
| Coordinates | 3251375..3251752 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1L6W4Z7 |
| Locus tag | EEL47_RS16355 | Protein ID | WP_070749977.1 |
| Coordinates | 3250917..3251285 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EEL47_RS16315 (3247479) | 3247479..3247674 | + | 196 | Protein_3104 | DUF905 family protein | - |
| EEL47_RS16325 (3247792) | 3247792..3248610 | + | 819 | WP_134800237.1 | DUF932 domain-containing protein | - |
| EEL47_RS16330 (3248610) | 3248610..3248855 | + | 246 | WP_000680584.1 | hypothetical protein | - |
| EEL47_RS16335 (3248949) | 3248949..3249428 | + | 480 | WP_000706976.1 | antirestriction protein | - |
| EEL47_RS16340 (3249442) | 3249442..3249918 | + | 477 | WP_001186742.1 | RadC family protein | - |
| EEL47_RS16345 (3249987) | 3249987..3250208 | + | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
| EEL47_RS16350 (3250223) | 3250223..3250867 | + | 645 | Protein_3110 | antitoxin of toxin-antitoxin stability system | - |
| EEL47_RS16355 (3250917) | 3250917..3251285 | + | 369 | WP_070749977.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EEL47_RS16360 (3251375) | 3251375..3251752 | + | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| EEL47_RS26365 (3251749) | 3251749..3251832 | + | 84 | Protein_3113 | DUF5983 family protein | - |
| EEL47_RS16365 (3251917) | 3251917..3252663 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| EEL47_RS16370 (3252678) | 3252678..3254219 | - | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
| EEL47_RS16375 (3254413) | 3254413..3254823 | + | 411 | Protein_3116 | DUF5983 family protein | - |
| EEL47_RS16380 (3254835) | 3254835..3255032 | + | 198 | WP_000839267.1 | DUF957 domain-containing protein | - |
| EEL47_RS16385 (3255117) | 3255117..3255965 | + | 849 | WP_001280510.1 | DUF4942 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gtrA / gtrB / gtrII | 3218095..3293763 | 75668 | |
| - | inside | Prophage | - | gtrA / gtrB / gtrII | 3244562..3293763 | 49201 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T113782 WP_000854726.1 NZ_CP033510:3251375-3251752 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T113782 NZ_CP033510:3251375-3251752 [Shigella flexneri]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13860.63 Da Isoelectric Point: 6.3177
>AT113782 WP_070749977.1 NZ_CP033510:3250917-3251285 [Shigella flexneri]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQVFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQVFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT113782 NZ_CP033510:3250917-3251285 [Shigella flexneri]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATTTGGACCAGGTCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATTTGGACCAGGTCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1EZ92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1L6W4Z7 |