Detailed information of TA system TA113766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 3961249..3961799
• Replicon: chromosome
• Accession: NZ_CP033507
• Organism: Mesorhizobium jarvisii strain ATCC 700743

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EB229_RS19450
• Protein ID: WP_081296083.1
• Coordinates: 3961249..3961545 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A6M7TQI6
• Locus tag: EB229_RS19455
• Protein ID: WP_027046965.1
• Coordinates: 3961545..3961799 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB229_RS19415	3956562..3956741	+	180	WP_027046966.1	CbtB-domain containing protein	-
EB229_RS19420	3956757..3957563	+	807	WP_064983981.1	CbtA family protein	-
EB229_RS19425	3957556..3958071	+	516	WP_064983983.1	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	-
EB229_RS19430	3958073..3958702	+	630	WP_019858756.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
EB229_RS19435	3958699..3959673	-	975	WP_064983985.1	cobalamin biosynthesis protein CobD	-
EB229_RS19440	3959672..3960718	+	1047	WP_081296082.1	threonine-phosphate decarboxylase	-
EB229_RS19445	3960715..3961224	+	510	WP_064983987.1	tyrosine phosphatase family protein	-
EB229_RS19450	3961249..3961545	-	297	WP_081296083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EB229_RS19455	3961545..3961799	-	255	WP_027046965.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EB229_RS19460	3961980..3962783	-	804	WP_064983990.1	creatininase family protein	-
EB229_RS19465	3962838..3963221	-	384	WP_019858748.1	RidA family protein	-
EB229_RS19470	3963487..3964491	+	1005	WP_064983992.1	ABC transporter substrate-binding protein	-
EB229_RS19475	3964504..3965328	+	825	WP_064983993.1	ABC transporter ATP-binding protein	-
EB229_RS19480	3965315..3966163	+	849	WP_038647435.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (6-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11253.93 Da
• Isoelectric Point: 6.3288

>T113766 WP_081296083.1 NZ_CP033507:c3961545-3961249 [Mesorhizobium jarvisii]
MGFRLSLAAEEDIIGIAEQGVRLFGAVQARQYHDELFAIFDLIAASPRMVRERLELSPPMRIHPFKAHLVVYRIEVDGDV
FIVRVRHGHEDWANEGTR

Nucleotide

• Length: 297 bp

>T113766 NZ_CP033507:c3961545-3961249 [Mesorhizobium jarvisii]
ATGGGATTTCGCCTTTCTTTAGCCGCGGAAGAGGACATCATCGGTATTGCCGAGCAAGGGGTGCGCCTGTTCGGTGCTGT
GCAGGCTAGACAGTATCATGACGAGTTGTTCGCGATCTTTGATCTGATCGCTGCCAGTCCCCGAATGGTACGGGAGCGGC
TTGAATTGTCGCCACCAATGCGTATCCATCCCTTCAAAGCCCATCTTGTCGTCTACCGGATAGAAGTCGACGGCGACGTG
TTCATTGTGCGGGTACGCCACGGGCACGAAGATTGGGCGAATGAAGGCACTCGATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9347.38 Da
• Isoelectric Point: 6.3108

>AT113766 WP_027046965.1 NZ_CP033507:c3961799-3961545 [Mesorhizobium jarvisii]
MATMNVSLPDPMKDWVEAQTETGRYANASDYVRDLIRRDQERNDNIAAMQRFVDDGLKSGIGNRSRDALFTEAVKRAGKS
PGNG

Nucleotide

• Length: 255 bp

>AT113766 NZ_CP033507:c3961799-3961545 [Mesorhizobium jarvisii]
ATGGCAACAATGAACGTATCATTGCCTGATCCGATGAAGGATTGGGTTGAGGCGCAAACCGAAACGGGTCGCTACGCCAA
CGCGAGCGACTATGTCCGCGATTTGATCCGTCGGGATCAGGAGCGCAACGACAACATTGCCGCCATGCAACGCTTTGTCG
ATGACGGATTGAAGAGTGGCATCGGCAATCGATCCAGGGACGCGCTCTTTACTGAGGCAGTCAAGCGCGCTGGAAAGTCA
CCCGGCAACGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6M7TQI6