Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3648138..3648904 Replicon chromosome
Accession NZ_CP033507
Organism Mesorhizobium jarvisii strain ATCC 700743

Toxin (Protein)


Gene name tacT Uniprot ID A0A6M7TS52
Locus tag EB229_RS17995 Protein ID WP_064984294.1
Coordinates 3648419..3648904 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6M7TJG1
Locus tag EB229_RS17990 Protein ID WP_064983733.1
Coordinates 3648138..3648419 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB229_RS17965 3643491..3644471 + 981 WP_064983728.1 ABC transporter permease -
EB229_RS17970 3644468..3645454 + 987 WP_019859204.1 ABC transporter permease -
EB229_RS17975 3645571..3646119 + 549 WP_064983730.1 gluconokinase -
EB229_RS17980 3646206..3646655 - 450 WP_019859201.1 Rrf2 family transcriptional regulator -
EB229_RS17985 3646905..3647891 - 987 WP_064983732.1 sulfate ABC transporter substrate-binding protein -
EB229_RS17990 3648138..3648419 + 282 WP_064983733.1 DUF1778 domain-containing protein Antitoxin
EB229_RS17995 3648419..3648904 + 486 WP_064984294.1 GNAT family N-acetyltransferase Toxin
EB229_RS18000 3648957..3649997 - 1041 WP_064983735.1 sulfate/molybdate ABC transporter ATP-binding protein -
EB229_RS18005 3650067..3650951 - 885 WP_019859196.1 sulfate ABC transporter permease subunit CysW -
EB229_RS18010 3650944..3651795 - 852 WP_019859195.1 sulfate ABC transporter permease subunit CysT -
EB229_RS18015 3651880..3652908 - 1029 WP_019859193.1 sulfate ABC transporter substrate-binding protein -
EB229_RS18020 3653113..3653844 - 732 WP_019859191.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(3-79)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17185.84 Da        Isoelectric Point: 9.4412

>T113764 WP_064984294.1 NZ_CP033507:3648419-3648904 [Mesorhizobium jarvisii]
MLSAPAPLAENHDLELFQSGTESLDQWLRRRARANQVGGASRTYVVAEGARVVGYYCLSSGGLDLAEAPGPIRRNMPDPI
PMVVLGRLAVDAGWQGKGLGAALLQDAVLRAGHAATILRIRGIFVHAISDEAKAFYEHYGFAASPKHPMTLVLSLKGLVK
A

Download         Length: 486 bp

>T113764 NZ_CP033507:3648419-3648904 [Mesorhizobium jarvisii]
ATGCTATCGGCGCCGGCGCCCCTGGCCGAAAACCACGATCTCGAACTTTTCCAAAGTGGGACTGAAAGCCTCGACCAATG
GCTGCGCCGTAGGGCGCGGGCCAACCAAGTCGGTGGCGCGTCTCGGACTTATGTGGTGGCGGAAGGCGCTCGGGTTGTCG
GCTATTACTGCCTGTCTTCGGGCGGGCTTGATCTTGCGGAGGCGCCTGGCCCCATCCGTCGCAACATGCCGGATCCCATC
CCAATGGTCGTACTCGGGCGCCTTGCCGTGGACGCAGGCTGGCAAGGCAAGGGGCTGGGTGCCGCGCTACTGCAAGACGC
CGTTCTGCGCGCCGGCCACGCCGCGACGATCCTCAGGATTCGCGGCATTTTCGTTCATGCCATATCGGATGAGGCGAAAG
CCTTCTACGAGCACTACGGCTTCGCGGCTTCTCCGAAGCATCCAATGACCTTGGTGCTATCGTTGAAGGGCCTGGTGAAA
GCTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10709.28 Da        Isoelectric Point: 8.5038

>AT113764 WP_064983733.1 NZ_CP033507:3648138-3648419 [Mesorhizobium jarvisii]
MTKAAPENHAKPVNLRIREDMRILIDRAAKIRGKTRSDFMIDAAYRSAEETLLDQTLIKVDPESYRHYLDILDKPPSGEG
FARLMNAPKPWQD

Download         Length: 282 bp

>AT113764 NZ_CP033507:3648138-3648419 [Mesorhizobium jarvisii]
ATGACAAAGGCCGCCCCTGAGAACCACGCCAAGCCTGTCAATCTGCGTATCCGAGAGGACATGCGCATACTAATTGACCG
CGCCGCGAAAATACGCGGGAAAACCCGCTCCGACTTCATGATCGACGCCGCCTACCGTTCGGCTGAGGAGACGCTGCTCG
ACCAGACCCTGATCAAGGTGGATCCGGAGAGTTACCGGCATTATCTCGACATCCTTGACAAACCGCCAAGCGGGGAGGGT
TTTGCGCGCCTTATGAACGCGCCCAAGCCATGGCAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M7TS52

Antitoxin

Source ID Structure
AlphaFold DB A0A6M7TJG1

References