Detailed information of TA system TA113762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4552608..4553143
• Replicon: chromosome
• Accession: NZ_CP033504
• Organism: Serratia sp. LS-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: EDY99_RS21720
• Protein ID: WP_033636570.1
• Coordinates: 4552868..4553143 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: EDY99_RS21715
• Protein ID: WP_033639076.1
• Coordinates: 4552608..4552868 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDY99_RS21695	4547927..4548577	+	651	WP_033645112.1	DcrB-related protein	-
EDY99_RS21700	4548618..4549223	+	606	WP_033645111.1	glutathione S-transferase	-
EDY99_RS21705	4549293..4550687	+	1395	WP_123062058.1	L-seryl-tRNA(Sec) selenium transferase	-
EDY99_RS21710	4550684..4552525	+	1842	WP_123062059.1	selenocysteine-specific translation elongation factor	-
EDY99_RS21715	4552608..4552868	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
EDY99_RS21720	4552868..4553143	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EDY99_RS21725	4553155..4554066	-	912	WP_033645108.1	LysR family transcriptional regulator	-
EDY99_RS21730	4554188..4554814	+	627	WP_033645107.1	LysE family translocator	-
EDY99_RS21735	4554868..4556115	-	1248	WP_033633516.1	MFS transporter	-
EDY99_RS21740	4556333..4557325	+	993	WP_123062060.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4552608..4561506	8898

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T113762 WP_033636570.1 NZ_CP033504:4552868-4553143 [Serratia sp. LS-1]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T113762 NZ_CP033504:4552868-4553143 [Serratia sp. LS-1]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT113762 WP_033639076.1 NZ_CP033504:4552608-4552868 [Serratia sp. LS-1]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT113762 NZ_CP033504:4552608-4552868 [Serratia sp. LS-1]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCGGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D971