Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4504588..4505189 Replicon chromosome
Accession NZ_CP033504
Organism Serratia sp. LS-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag EDY99_RS21500 Protein ID WP_025304766.1
Coordinates 4504588..4504968 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag EDY99_RS21505 Protein ID WP_025304767.1
Coordinates 4504968..4505189 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDY99_RS21475 4499835..4501115 + 1281 WP_033645140.1 DUF3748 domain-containing protein -
EDY99_RS21480 4501146..4501493 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
EDY99_RS21485 4501803..4502216 + 414 WP_004933919.1 heat shock chaperone IbpA -
EDY99_RS21490 4502323..4502751 + 429 WP_004933922.1 heat shock chaperone IbpB -
EDY99_RS21495 4502919..4504577 + 1659 WP_069101019.1 putative transporter -
EDY99_RS21500 4504588..4504968 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
EDY99_RS21505 4504968..4505189 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
EDY99_RS21510 4505263..4506513 - 1251 WP_033645138.1 valine--pyruvate transaminase -
EDY99_RS21515 4507526..4508305 + 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
EDY99_RS21520 4508385..4509524 + 1140 WP_046687995.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T113761 WP_025304766.1 NZ_CP033504:c4504968-4504588 [Serratia sp. LS-1]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T113761 NZ_CP033504:c4504968-4504588 [Serratia sp. LS-1]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAGGGACGTTCT
GGTCGAGTATCACATCAATCCGGCCATCAGCGCCATCACCTGGATGGAAGTGATGGTAGGTGCTAAAAAACAGGGTCCGG
CACTGGAGCTGAAAACACGTCAGTTTTTAGGGCAATTTCTGCTGCTGCCTATTACCGATGAAGTCGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAACTGCCAGACGCCATTATCTGGGCCACCGCGCAGGTGGGATTCCGGATGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTGATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT113761 WP_025304767.1 NZ_CP033504:c4505189-4504968 [Serratia sp. LS-1]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT113761 NZ_CP033504:c4505189-4504968 [Serratia sp. LS-1]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGATAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATTCGTCAAGCAGTCTCCCGCTATCTGACGGAGAACCACGTGGAAGATCCCAGCAACGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGAGTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References