Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3563676..3564345 Replicon chromosome
Accession NZ_CP033504
Organism Serratia sp. LS-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B4GZI3
Locus tag EDY99_RS17025 Protein ID WP_042785308.1
Coordinates 3563676..3564098 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag EDY99_RS17030 Protein ID WP_019455657.1
Coordinates 3564079..3564345 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDY99_RS17005 3559603..3561336 - 1734 WP_122017015.1 single-stranded-DNA-specific exonuclease RecJ -
EDY99_RS17010 3561343..3562059 - 717 WP_123061949.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EDY99_RS17015 3562086..3562985 - 900 WP_033644935.1 site-specific tyrosine recombinase XerD -
EDY99_RS17020 3563092..3563610 + 519 WP_033635825.1 flavodoxin FldB -
EDY99_RS17025 3563676..3564098 - 423 WP_042785308.1 protein YgfX Toxin
EDY99_RS17030 3564079..3564345 - 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
EDY99_RS17035 3564666..3565658 + 993 WP_099783413.1 tRNA-modifying protein YgfZ -
EDY99_RS17040 3565697..3566194 - 498 WP_060422863.1 DUF2165 domain-containing protein -
EDY99_RS17045 3566345..3567019 - 675 WP_123061950.1 hemolysin III family protein -
EDY99_RS17050 3567203..3567811 + 609 WP_047573791.1 HD domain-containing protein -
EDY99_RS17055 3567852..3568778 - 927 WP_033644768.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16527.59 Da        Isoelectric Point: 10.8114

>T113758 WP_042785308.1 NZ_CP033504:c3564098-3563676 [Serratia sp. LS-1]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQD

Download         Length: 423 bp

>T113758 NZ_CP033504:c3564098-3563676 [Serratia sp. LS-1]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTCTCTCTGTTGACCCACGGCGTCCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCTGCGGTGCAGGGTGAACTGCGGCTGCTGGCGGACAGGCGTTTCAGTTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGTTACAGCCTATGGAGGGCAAAAAGCG
CCGTCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAACAAGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT113758 WP_019455657.1 NZ_CP033504:c3564345-3564079 [Serratia sp. LS-1]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT113758 NZ_CP033504:c3564345-3564079 [Serratia sp. LS-1]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTCATCCGTCTGCTCGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAAAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References