Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1097417..1097942 Replicon chromosome
Accession NZ_CP033504
Organism Serratia sp. LS-1

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GJ35
Locus tag EDY99_RS05385 Protein ID WP_033633469.1
Coordinates 1097417..1097701 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag EDY99_RS05390 Protein ID WP_004928423.1
Coordinates 1097691..1097942 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDY99_RS05360 1092621..1093754 + 1134 WP_004938650.1 putrescine ABC transporter ATP-binding subunit PotG -
EDY99_RS05365 1093779..1094741 + 963 WP_042784087.1 putrescine ABC transporter permease PotH -
EDY99_RS05370 1094738..1095583 + 846 WP_033642528.1 putrescine ABC transporter permease PotI -
EDY99_RS05375 1095745..1096224 + 480 WP_047024958.1 YbjO family protein -
EDY99_RS05380 1096293..1097420 + 1128 WP_122004040.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
EDY99_RS05385 1097417..1097701 - 285 WP_033633469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EDY99_RS05390 1097691..1097942 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
EDY99_RS05395 1098044..1098778 - 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
EDY99_RS05400 1098979..1099647 - 669 WP_025302241.1 arginine ABC transporter permease ArtM -
EDY99_RS05405 1099647..1100363 - 717 WP_025159684.1 arginine ABC transporter permease ArtQ -
EDY99_RS05410 1100373..1101104 - 732 WP_004928409.1 arginine ABC transporter substrate-binding protein -
EDY99_RS05415 1101137..1101865 - 729 WP_089192582.1 arginine ABC transporter ATP-binding protein ArtP -
EDY99_RS05420 1102130..1102672 - 543 WP_033642535.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.91 Da        Isoelectric Point: 10.6941

>T113747 WP_033633469.1 NZ_CP033504:c1097701-1097417 [Serratia sp. LS-1]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T113747 NZ_CP033504:c1097701-1097417 [Serratia sp. LS-1]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT113747 WP_004928423.1 NZ_CP033504:c1097942-1097691 [Serratia sp. LS-1]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT113747 NZ_CP033504:c1097942-1097691 [Serratia sp. LS-1]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCTGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAATACCTGGAAGATATTGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GJ35

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References