Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4106818..4107475 Replicon chromosome
Accession NZ_CP033466
Organism Enterobacter cloacae strain E3442

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag EEI76_RS19850 Protein ID WP_022649305.1
Coordinates 4107065..4107475 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag EEI76_RS19845 Protein ID WP_003863437.1
Coordinates 4106818..4107084 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEI76_RS19825 4102250..4103683 - 1434 WP_123060912.1 6-phospho-beta-glucosidase BglA -
EEI76_RS19830 4103800..4104531 - 732 WP_123060913.1 MurR/RpiR family transcriptional regulator -
EEI76_RS19835 4104798..4105457 + 660 WP_003863433.1 hemolysin III family protein -
EEI76_RS19840 4105543..4106523 - 981 WP_003863435.1 tRNA-modifying protein YgfZ -
EEI76_RS19845 4106818..4107084 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
EEI76_RS19850 4107065..4107475 + 411 WP_022649305.1 protein YgfX Toxin
EEI76_RS19855 4107477..4107998 - 522 WP_003863440.1 flavodoxin FldB -
EEI76_RS19860 4108100..4108996 + 897 WP_023314794.1 site-specific tyrosine recombinase XerD -
EEI76_RS19865 4109025..4109738 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EEI76_RS19870 4109744..4111477 + 1734 WP_123060914.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T113737 WP_022649305.1 NZ_CP033466:4107065-4107475 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T113737 NZ_CP033466:4107065-4107475 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTACTGTCGTTTGTAGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGTCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT113737 WP_003863437.1 NZ_CP033466:4106818-4107084 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT113737 NZ_CP033466:4106818-4107084 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References