Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 610805..611364 Replicon chromosome
Accession NZ_CP033457
Organism Vibrio alginolyticus strain SNU_SP1

Toxin (Protein)


Gene name relE Uniprot ID A0A2I3C6F2
Locus tag EEA47_RS02825 Protein ID WP_005377065.1
Coordinates 611086..611364 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I3C6F3
Locus tag EEA47_RS02820 Protein ID WP_005487956.1
Coordinates 610805..611089 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEA47_RS02755 (EEA47_02845) 605910..606002 - 93 WP_074050578.1 DUF3265 domain-containing protein -
EEA47_RS02760 (EEA47_02850) 606017..606526 - 510 WP_020840826.1 hypothetical protein -
EEA47_RS02765 (EEA47_02855) 606536..606628 - 93 WP_238842957.1 DUF3265 domain-containing protein -
EEA47_RS02770 (EEA47_02860) 606651..607127 - 477 WP_238842956.1 hypothetical protein -
EEA47_RS02775 (EEA47_02865) 607160..607444 - 285 WP_238842955.1 hypothetical protein -
EEA47_RS02780 (EEA47_02870) 607609..607701 - 93 WP_193248809.1 DUF3265 domain-containing protein -
EEA47_RS02785 (EEA47_02880) 607716..608618 - 903 WP_238842954.1 restriction endonuclease -
EEA47_RS02790 (EEA47_02885) 608654..608783 - 130 Protein_555 DUF3265 domain-containing protein -
EEA47_RS02795 (EEA47_02890) 609201..609290 - 90 WP_080619587.1 DUF3265 domain-containing protein -
EEA47_RS02800 (EEA47_02895) 609315..609650 - 336 WP_158173982.1 TonB family protein -
EEA47_RS02805 609733..609810 - 78 Protein_558 DUF3265 domain-containing protein -
EEA47_RS02810 (EEA47_02900) 609864..610181 + 318 WP_213906424.1 hypothetical protein -
EEA47_RS02815 (EEA47_02905) 610192..610581 + 390 WP_268207097.1 hypothetical protein -
EEA47_RS02820 (EEA47_02910) 610805..611089 + 285 WP_005487956.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EEA47_RS02825 (EEA47_02915) 611086..611364 + 279 WP_005377065.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EEA47_RS02830 (EEA47_02920) 611393..611485 - 93 WP_080374080.1 DUF3265 domain-containing protein -
EEA47_RS02835 (EEA47_02925) 611511..611873 - 363 WP_005386966.1 VOC family protein -
EEA47_RS02840 (EEA47_02930) 612034..612414 - 381 WP_031382130.1 glyoxalase -
EEA47_RS02845 (EEA47_02935) 612447..612536 - 90 WP_140170336.1 DUF3265 domain-containing protein -
EEA47_RS02850 (EEA47_02940) 613166..613546 - 381 WP_031382130.1 glyoxalase -
EEA47_RS02855 (EEA47_02945) 613579..613707 - 129 WP_099098883.1 DUF3265 domain-containing protein -
EEA47_RS02860 (EEA47_02955) 614238..614678 - 441 WP_140361383.1 hypothetical protein -
EEA47_RS02865 (EEA47_02960) 614816..614908 - 93 WP_080374080.1 DUF3265 domain-containing protein -
EEA47_RS02870 (EEA47_02965) 614934..615296 - 363 WP_005386966.1 VOC family protein -
EEA47_RS02875 (EEA47_02970) 615349..615441 - 93 WP_005494820.1 DUF3265 domain-containing protein -
EEA47_RS02880 (EEA47_02975) 615456..615860 - 405 WP_213906130.1 hypothetical protein -
EEA47_RS02885 (EEA47_02980) 615894..616004 - 111 WP_262660237.1 DUF3265 domain-containing protein -
EEA47_RS02890 (EEA47_02985) 616012..616296 - 285 WP_021452995.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vopD / vopB / vcrH / vcrV / vcrG / vcrR / vcrD / vscY / vscX / sycN/vcr2 / tyeA/vcr1 / vopN / vscN / vscO / vscQ / vscR / vscS / vscT / vscU / vopQ / vecA / vopR / vopS / vscL / vscK / vscJ / vscI / vscG / vscF / vscD / vscC / vscB / exsD / exsA / vxsC 367280..622806 255526
- inside Integron - - 606017..639906 33889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T113714 WP_005377065.1 NZ_CP033457:611086-611364 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T113714 NZ_CP033457:611086-611364 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11082.40 Da        Isoelectric Point: 9.2167

>AT113714 WP_005487956.1 NZ_CP033457:610805-611089 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT113714 NZ_CP033457:610805-611089 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I3C6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A2I3C6F3

References