Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6793932..6794437 Replicon chromosome
Accession NZ_CP033439
Organism Pseudomonas aeruginosa strain SP4528

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag D8668_RS32125 Protein ID WP_031640969.1
Coordinates 6793932..6794213 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag D8668_RS32130 Protein ID WP_003083775.1
Coordinates 6794210..6794437 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8668_RS32100 6789183..6790532 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
D8668_RS32105 6790581..6791267 + 687 WP_003083762.1 FadR family transcriptional regulator -
D8668_RS32110 6791368..6792102 + 735 WP_003128333.1 GntR family transcriptional regulator -
D8668_RS32115 6792306..6792692 + 387 WP_003083767.1 aegerolysin family protein -
D8668_RS32120 6792724..6793632 - 909 WP_033990895.1 LysR family transcriptional regulator -
D8668_RS32125 6793932..6794213 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
D8668_RS32130 6794210..6794437 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
D8668_RS32135 6794613..6795233 - 621 WP_003101226.1 hypothetical protein -
D8668_RS32140 6795334..6795834 + 501 WP_003101228.1 LEA type 2 family protein -
D8668_RS32145 6795906..6796247 + 342 WP_003101229.1 alkylphosphonate utilization protein -
D8668_RS32150 6796329..6797756 - 1428 WP_003083784.1 GABA permease -
D8668_RS32155 6797925..6799418 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T113713 WP_031640969.1 NZ_CP033439:c6794213-6793932 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T113713 NZ_CP033439:c6794213-6793932 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT113713 WP_003083775.1 NZ_CP033439:c6794437-6794210 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT113713 NZ_CP033439:c6794437-6794210 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References