Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 6708074..6708642 Replicon chromosome
Accession NZ_CP033439
Organism Pseudomonas aeruginosa strain SP4528

Toxin (Protein)


Gene name parE Uniprot ID A0A0D0R3P1
Locus tag D8668_RS31695 Protein ID WP_011222050.1
Coordinates 6708349..6708642 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6M3UV67
Locus tag D8668_RS31690 Protein ID WP_011222051.1
Coordinates 6708074..6708361 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8668_RS31660 6703350..6704189 + 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
D8668_RS31670 6704317..6704817 + 501 WP_000376623.1 GNAT family N-acetyltransferase -
D8668_RS31675 6704786..6705778 - 993 WP_001381192.1 TniB family NTP-binding protein -
D8668_RS31680 6705781..6707460 - 1680 WP_000179844.1 DDE-type integrase/transposase/recombinase -
D8668_RS31685 6707695..6707901 + 207 WP_033991586.1 hypothetical protein -
D8668_RS31690 6708074..6708361 + 288 WP_011222051.1 CopG family ribbon-helix-helix protein Antitoxin
D8668_RS31695 6708349..6708642 + 294 WP_011222050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8668_RS32765 6708580..6708891 - 312 WP_052150402.1 hypothetical protein -
D8668_RS31700 6708927..6709112 - 186 Protein_6105 multidrug transporter -
D8668_RS31710 6709541..6709783 + 243 WP_000844627.1 transposase -
D8668_RS31715 6709815..6710465 - 651 WP_000164043.1 tetracycline resistance transcriptional repressor TetR(A) -
D8668_RS31720 6710571..6711761 + 1191 WP_033991588.1 tetracycline efflux MFS transporter Tet(A) -
D8668_RS31725 6712495..6713394 - 900 WP_032494864.1 class A extended-spectrum beta-lactamase VEB-9 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10890.71 Da        Isoelectric Point: 10.8518

>T113712 WP_011222050.1 NZ_CP033439:6708349-6708642 [Pseudomonas aeruginosa]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Download         Length: 294 bp

>T113712 NZ_CP033439:6708349-6708642 [Pseudomonas aeruginosa]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10922.19 Da        Isoelectric Point: 5.1897

>AT113712 WP_011222051.1 NZ_CP033439:6708074-6708361 [Pseudomonas aeruginosa]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK

Download         Length: 288 bp

>AT113712 NZ_CP033439:6708074-6708361 [Pseudomonas aeruginosa]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0R3P1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3UV67

References