113707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1125308..1125894 Replicon chromosome
Accession NZ_CP033439
Organism Pseudomonas aeruginosa strain SP4528

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag D8668_RS05185 Protein ID WP_003120987.1
Coordinates 1125308..1125607 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag D8668_RS05190 Protein ID WP_003448662.1
Coordinates 1125604..1125894 (+) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8668_RS05165 1120421..1120954 - 534 WP_004352829.1 type IV pilus biogenesis protein PilP -
D8668_RS05170 1120944..1122269 - 1326 WP_022579625.1 type 4b pilus protein PilO2 -
D8668_RS05175 1122273..1123982 - 1710 WP_023093673.1 PilN family type IVB pilus formation outer membrane protein -
D8668_RS05180 1123982..1125106 - 1125 WP_023093672.1 TcpQ domain-containing protein -
D8668_RS05185 1125308..1125607 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D8668_RS05190 1125604..1125894 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
D8668_RS05195 1125977..1126312 - 336 WP_022579623.1 hypothetical protein -
D8668_RS05200 1126451..1128427 - 1977 WP_022579622.1 DEAD/DEAH box helicase -
D8668_RS05205 1128424..1130313 - 1890 WP_033989533.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1065389..1155743 90354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T113707 WP_003120987.1 NZ_CP033439:1125308-1125607 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

>T113707 NZ_CP033439:1125308-1125607 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT113707 WP_003448662.1 NZ_CP033439:1125604-1125894 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT113707 NZ_CP033439:1125604-1125894 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G8CP73


Antitoxin

Source ID Structure

References