113705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3256464..3257069 Replicon chromosome
Accession NZ_CP033433
Organism Cohnella candidum strain 18JY8-7

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EAV92_RS14905 Protein ID WP_123041833.1
Coordinates 3256464..3256814 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EAV92_RS14910 Protein ID WP_206424329.1
Coordinates 3256818..3257069 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAV92_RS14890 3251867..3252343 - 477 WP_123041830.1 Rrf2 family transcriptional regulator -
EAV92_RS14895 3252522..3254708 - 2187 WP_123041831.1 RNA-binding transcriptional accessory protein -
EAV92_RS14900 3254856..3256274 - 1419 WP_123041832.1 NAD(P)/FAD-dependent oxidoreductase -
EAV92_RS14905 3256464..3256814 - 351 WP_123041833.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EAV92_RS14910 3256818..3257069 - 252 WP_206424329.1 ribbon-helix-helix protein, CopG family Antitoxin
EAV92_RS14915 3257245..3258414 - 1170 WP_123041835.1 alanine racemase -
EAV92_RS14920 3258571..3259677 - 1107 WP_123041836.1 outer membrane lipoprotein carrier protein LolA -
EAV92_RS14925 3259830..3260105 - 276 WP_123043749.1 hypothetical protein -
EAV92_RS14930 3260487..3260675 + 189 WP_123041837.1 hypothetical protein -
EAV92_RS14935 3260691..3261437 + 747 WP_123041838.1 polysaccharide deacetylase family protein -
EAV92_RS14940 3261510..3261860 + 351 WP_123041839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12877.90 Da        Isoelectric Point: 5.6439

>T113705 WP_123041833.1 NZ_CP033433:c3256814-3256464 [Cohnella candidum]
MIVKRGDVFYADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIEAKTHGMEKDSVILLEQI
RTIDKQRLTDKITHLEDDTMRKVDEALQISVGLIDF

Download         Length: 351 bp

>T113705 NZ_CP033433:c3256814-3256464 [Cohnella candidum]
TTGATCGTCAAGCGCGGGGATGTTTTTTACGCCGATTTGTCGCCGGTCGTCGGCTCGGAACAGGGCGGAGTGCGCCCCGT
GCTGGTGATCCAGAACGATATCGGCAACCGCTTCAGCCCTACGGTCATCGTGGCGGCCATCACGGCGCAAATCCAGAAAG
CGAAGCTTCCGACGCACGTCGAGATCGAAGCGAAGACGCACGGGATGGAGAAGGATTCCGTCATCCTGCTGGAGCAGATC
CGCACGATCGACAAGCAGAGGCTGACGGACAAAATCACGCACCTCGAGGACGACACGATGCGCAAAGTGGATGAAGCTTT
GCAGATCAGCGTCGGTTTGATCGATTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9638.11 Da        Isoelectric Point: 6.4720

>AT113705 WP_206424329.1 NZ_CP033433:c3257069-3256818 [Cohnella candidum]
MISLPDHLLREVDFVVEKENTNRSEVIRQAMKQYLVERKKRMIRDAMQRGYLEMAKINLNMASEAFHAEEDAESTLGRLV
SGV

Download         Length: 252 bp

>AT113705 NZ_CP033433:c3257069-3256818 [Cohnella candidum]
ATGATCAGTTTGCCGGATCATCTGCTGCGCGAAGTCGACTTCGTCGTGGAGAAGGAAAATACCAATCGCAGCGAAGTGAT
CCGCCAAGCGATGAAACAATACTTGGTGGAGCGCAAGAAACGGATGATTCGCGACGCGATGCAGCGCGGGTATTTGGAAA
TGGCGAAAATCAACCTGAACATGGCATCCGAAGCTTTCCACGCCGAAGAAGATGCCGAAAGCACGCTCGGGCGCCTCGTT
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References