Detailed information of TA system TA113704

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3461146..3461783
• Replicon: chromosome
• Accession: NZ_CP033431
• Organism: Burkholderia gladioli strain Burkholderia gladioli Co14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EDD84_RS34340
• Protein ID: WP_123038357.1
• Coordinates: 3461146..3461547 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A3G3LHG1
• Locus tag: EDD84_RS34345
• Protein ID: WP_036035569.1
• Coordinates: 3461547..3461783 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDD84_RS34325	3456395..3457435	-	1041	WP_123038355.1	D-cysteine desulfhydrase family protein	-
EDD84_RS34330	3457610..3458137	-	528	WP_025099235.1	Lrp/AsnC family transcriptional regulator	-
EDD84_RS34335	3458309..3461029	+	2721	WP_123038356.1	alpha-ketoglutarate dehydrogenase	-
EDD84_RS34340	3461146..3461547	-	402	WP_123038357.1	type II toxin-antitoxin system VapC family toxin	Toxin
EDD84_RS34345	3461547..3461783	-	237	WP_036035569.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EDD84_RS34350	3461992..3462597	-	606	WP_123038622.1	2OG-Fe(II) oxygenase	-
EDD84_RS34355	3462677..3466153	-	3477	WP_123038358.1	autotransporter domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14824.05 Da
• Isoelectric Point: 6.9522

>T113704 WP_123038357.1 NZ_CP033431:c3461547-3461146 [Burkholderia gladioli]
MPQFMLDTNMCIYLMKNQPEQVARRFAKCFVGDVAMSAITYAELEYGVTVSAGRTRERRNLAALVEDIPVVPFDAAAASA
YGPLREATRERKKDQLDKLIAAHSLALGVVLVTNNERDFASYPGVRLENWLNA

Nucleotide

• Length: 402 bp

>T113704 NZ_CP033431:c3461547-3461146 [Burkholderia gladioli]
ATGCCGCAATTCATGCTCGACACGAATATGTGCATATACCTGATGAAAAATCAGCCGGAGCAGGTTGCACGGAGATTCGC
AAAGTGTTTTGTTGGCGATGTGGCGATGTCGGCGATCACCTACGCCGAGCTCGAGTATGGCGTGACGGTGTCGGCCGGTC
GCACTCGCGAACGCCGGAATCTTGCGGCGCTCGTGGAGGACATTCCGGTGGTGCCCTTCGATGCCGCTGCCGCTTCGGCT
TATGGTCCCCTTCGAGAGGCGACCCGGGAGCGCAAAAAGGATCAACTGGACAAGTTGATTGCAGCCCACTCGCTTGCGCT
TGGCGTCGTGCTCGTCACGAATAACGAACGCGATTTCGCCAGCTACCCCGGCGTTCGACTGGAGAACTGGCTGAACGCCT
GA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8943.06 Da
• Isoelectric Point: 4.8781

>AT113704 WP_036035569.1 NZ_CP033431:c3461783-3461547 [Burkholderia gladioli]
MHTTRVFRNGDSQAVRIPAEIAFESSDVEVEIERIGDEIRIRPIRCPLTGVLRKFEKFGPDFMTEGRGDQEHAERDAL

Nucleotide

• Length: 237 bp

>AT113704 NZ_CP033431:c3461783-3461547 [Burkholderia gladioli]
ATGCATACGACCCGGGTATTCCGCAACGGAGATTCGCAAGCGGTCAGAATTCCGGCAGAAATAGCATTCGAAAGTAGCGA
TGTCGAGGTTGAAATTGAACGCATCGGCGACGAGATTCGCATCCGGCCCATTCGTTGCCCGTTGACCGGCGTGCTGCGGA
AGTTCGAAAAATTCGGGCCGGACTTCATGACCGAAGGCCGCGGCGACCAGGAGCACGCCGAACGGGATGCCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3G3LHG1