Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3128441..3130284 Replicon chromosome
Accession NZ_CP033431
Organism Burkholderia gladioli strain Burkholderia gladioli Co14

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag EDD84_RS32960 Protein ID WP_123038610.1
Coordinates 3129319..3130284 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EDD84_RS32955 Protein ID WP_042285493.1
Coordinates 3128441..3129301 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDD84_RS32935 3123585..3125075 - 1491 WP_036038826.1 aldehyde dehydrogenase -
EDD84_RS32940 3125155..3125988 - 834 WP_123038241.1 aspartate dehydrogenase -
EDD84_RS32945 3125981..3127654 - 1674 WP_123038242.1 thiamine pyrophosphate-binding protein -
EDD84_RS32950 3127647..3128444 - 798 WP_123038243.1 SDR family oxidoreductase -
EDD84_RS32955 3128441..3129301 - 861 WP_042285493.1 IclR family transcriptional regulator Antitoxin
EDD84_RS32960 3129319..3130284 - 966 WP_123038610.1 alpha/beta fold hydrolase Toxin
EDD84_RS32965 3130311..3130838 - 528 WP_036038832.1 cupin domain-containing protein -
EDD84_RS32970 3130937..3131707 - 771 WP_036038834.1 SDR family oxidoreductase -
EDD84_RS32975 3131700..3132809 - 1110 WP_036038836.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
EDD84_RS32980 3132851..3133162 - 312 WP_025097963.1 hypothetical protein -
EDD84_RS32985 3133165..3133482 - 318 WP_013689902.1 non-heme iron oxygenase ferredoxin subunit -
EDD84_RS32990 3133897..3134976 + 1080 WP_017921239.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(66-305)

Antitoxin

Transcription regulator IclR, N-terminal

(25-73)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 32583.03 Da        Isoelectric Point: 7.0325

>T113703 WP_123038610.1 NZ_CP033431:c3130284-3129319 [Burkholderia gladioli]
MSEIDPRGAEAEAGPDAALAARLGQFPARRIAIGEAGLIGWRESGPAQGAGGSTARAAAGERALPVVLLHGIGSGAASWL
AQLDTLGASRRVLAWDAPGYGESTPVAPASPLAADYAASLAGWLDALAIERCVLVGHSLGAIVAGAFARRHAGRLAGLLL
VSPAAGYGAAPAATRNERRDARLAMLAALGPAGMAEQRSANMLSAHAGEAARAWVRRVMAQVKPAGYTQATHLLANADLA
ADLAAWRAMTDAAGAARVEVMVGAEDGITPPNACEPVAAAAGVALRIVPRAGHAGYVEAPERYSELIGAFCARCDESWRQ
A

Download         Length: 966 bp

>T113703 NZ_CP033431:c3130284-3129319 [Burkholderia gladioli]
ATGAGCGAAATCGATCCGCGCGGGGCCGAGGCAGAGGCCGGGCCCGACGCGGCCCTGGCCGCCCGGCTCGGGCAGTTTCC
GGCGCGGCGCATCGCCATTGGCGAAGCCGGGCTGATCGGCTGGCGCGAATCGGGTCCAGCGCAGGGGGCCGGCGGTTCGA
CGGCACGCGCGGCCGCTGGCGAGCGGGCATTGCCGGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCTCGTGGCTG
GCCCAGCTCGACACGCTCGGCGCGTCGCGTCGCGTGCTGGCCTGGGACGCGCCCGGTTATGGCGAATCGACGCCGGTCGC
GCCGGCCTCGCCGCTGGCGGCCGATTACGCGGCGTCGCTGGCCGGCTGGCTCGACGCGCTCGCCATCGAGCGCTGCGTGC
TGGTGGGGCACTCGCTCGGCGCGATCGTGGCCGGCGCCTTCGCGCGCCGGCATGCCGGGCGGCTGGCCGGCTTGCTGCTG
GTTTCGCCGGCCGCCGGCTACGGCGCGGCGCCGGCCGCCACGCGCAACGAACGGCGCGACGCGCGGCTCGCGATGCTGGC
CGCGCTCGGGCCCGCCGGCATGGCCGAACAACGCAGCGCCAACATGCTGTCGGCGCATGCCGGCGAGGCCGCCCGCGCCT
GGGTGCGCCGCGTGATGGCGCAGGTGAAGCCGGCCGGCTACACGCAGGCCACCCACCTGCTCGCGAACGCCGACCTGGCC
GCCGATCTCGCCGCCTGGCGGGCGATGACCGACGCCGCCGGCGCCGCGCGCGTGGAGGTGATGGTGGGCGCCGAGGACGG
CATCACGCCGCCGAACGCCTGCGAACCGGTCGCGGCGGCGGCCGGCGTGGCGCTGCGCATCGTGCCGCGCGCCGGCCATG
CCGGCTACGTGGAGGCACCCGAGCGCTACTCAGAGCTGATCGGCGCGTTCTGCGCGCGCTGCGACGAATCATGGAGACAG
GCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31033.35 Da        Isoelectric Point: 6.5132

>AT113703 WP_042285493.1 NZ_CP033431:c3129301-3128441 [Burkholderia gladioli]
MRSEPADSGAPEADAANGAYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNY
RLGVAVLRLGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSAAPAFSSIRVNVGTRLPAHATTHG
HVLMGDLSEAELRALYPERQLERATRATPDSLEALLALVREDAARGYGISNASFERGISVVTAPVRNDTQRIVAAVTVTV
PKPEIDAALIADGLVEKVVRAANELSRRLNYRSDDENSYLKALGLR

Download         Length: 861 bp

>AT113703 NZ_CP033431:c3129301-3128441 [Burkholderia gladioli]
CTGCGAAGCGAGCCGGCCGACAGCGGTGCGCCCGAGGCGGATGCCGCGAACGGCGCCTACGTGGTACCTGGCCTCGAACG
CGGGCTGCGGATCCTCGCGGAATTCTCGCCGCGCGAGCCGGTGCTGGGCGCGCCGGAATTGTCGAAGCGGCTCGGCATTC
CGCGCACCACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTGGGCTTCCTGGAGCGCGCCGACAAGGACCGCAATTAC
CGGCTCGGCGTGGCGGTGCTGCGCCTGGGCTTCGAATACTTGAGCTCGCTGGAGCTGACCGACCTGGGCCTGCCGGTGAT
CGAGGGCCTGCGCGAGGCGACCGGCTTCACCACCCATATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCCAAGG
CGCAGAGCGCGGCGCCGGCCTTCAGCTCGATTCGCGTCAACGTCGGCACGCGGCTGCCCGCGCATGCCACCACCCACGGC
CACGTGCTGATGGGCGACCTGAGCGAGGCCGAGCTGCGCGCGCTGTACCCCGAGCGCCAGCTCGAACGCGCCACGCGCGC
CACGCCCGACAGCCTGGAGGCGCTGCTCGCGCTGGTCCGCGAGGATGCCGCGCGCGGCTACGGCATCAGCAACGCCTCGT
TCGAGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGCGCATCGTGGCGGCCGTCACGGTGACGGTG
CCCAAACCCGAGATCGACGCGGCGCTGATCGCCGACGGCCTGGTCGAGAAGGTCGTGAGGGCGGCCAATGAACTGTCGCG
GCGGCTCAATTACCGCTCCGATGATGAGAACTCCTATCTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References