Detailed information of TA system TA113701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1981379..1982021
• Replicon: chromosome
• Accession: NZ_CP033431
• Organism: Burkholderia gladioli strain Burkholderia gladioli Co14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0M2Q595
• Locus tag: EDD84_RS28460
• Protein ID: WP_046582149.1
• Coordinates: 1981599..1982021 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EDD84_RS28455
• Protein ID: WP_123038586.1
• Coordinates: 1981379..1981612 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDD84_RS28440	1977346..1977594	-	249	WP_013690725.1	acyl carrier protein	-
EDD84_RS28445	1977720..1979486	-	1767	WP_123037874.1	AMP-binding protein	-
EDD84_RS28450	1980073..1981062	+	990	WP_036033831.1	LysR family transcriptional regulator	-
EDD84_RS28455	1981379..1981612	+	234	WP_123038586.1	DNA-binding protein	Antitoxin
EDD84_RS28460	1981599..1982021	+	423	WP_046582149.1	type II toxin-antitoxin system VapC family toxin	Toxin
EDD84_RS28465	1982143..1982823	-	681	WP_036033825.1	deoxyribose-phosphate aldolase	-
EDD84_RS28470	1982973..1983743	+	771	WP_017918829.1	DNA-binding transcriptional repressor DeoR	-
EDD84_RS28475	1983763..1984845	-	1083	WP_123037875.1	aldose 1-epimerase family protein	-
EDD84_RS28480	1984848..1986221	-	1374	WP_123037876.1	L-fucose:H+ symporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15618.94 Da
• Isoelectric Point: 9.9428

>T113701 WP_046582149.1 NZ_CP033431:1981599-1982021 [Burkholderia gladioli]
MYLIDANVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDKSQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRSEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Nucleotide

• Length: 423 bp

>T113701 NZ_CP033431:1981599-1982021 [Burkholderia gladioli]
ATGTATTTGATTGACGCCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGTGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGGCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACAAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCTCGGAACACTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGATGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8542.65 Da
• Isoelectric Point: 5.0618

>AT113701 WP_123038586.1 NZ_CP033431:1981379-1981612 [Burkholderia gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHREILARALREPQRKTFAQVLMGMPNVGSDADFARVDDGEAANVFD

Nucleotide

• Length: 234 bp

>AT113701 NZ_CP033431:1981379-1981612 [Burkholderia gladioli]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGAAATCCTGGCAAGGGCGCTGCGCGAGCCGCAACGCAAGACATTCGCGCAAGTGCTGATGG
GCATGCCGAACGTCGGTAGCGATGCCGATTTTGCGCGCGTGGACGATGGCGAGGCGGCGAATGTATTTGATTGA

Structures

Toxin

• AlphaFold DB: A0A0M2Q595