Detailed information of TA system TA113697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3801203..3802441
• Replicon: chromosome
• Accession: NZ_CP033430
• Organism: Burkholderia gladioli strain Burkholderia gladioli Co14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3G3LAL0
• Locus tag: EDD84_RS18070
• Protein ID: WP_036040953.1
• Coordinates: 3801203..3801787 (-)
• Length: 195 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EDD84_RS18075
• Protein ID: WP_206427631.1
• Coordinates: 3801890..3802441 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDD84_RS18035	3796487..3796891	+	405	WP_164465590.1	DUF302 domain-containing protein	-
EDD84_RS18040	3797016..3797978	-	963	WP_036040951.1	AraC family transcriptional regulator	-
EDD84_RS36855	3798172..3798999	-	828	WP_164465591.1	lytic transglycosylase domain-containing protein	-
EDD84_RS18055	3799404..3800150	-	747	WP_052143183.1	hypothetical protein	-
EDD84_RS36860	3800329..3800700	-	372	WP_155301781.1	hypothetical protein	-
EDD84_RS18070	3801203..3801787	-	585	WP_036040953.1	HD domain-containing protein	Toxin
EDD84_RS18075	3801890..3802441	-	552	WP_206427631.1	helix-turn-helix domain-containing protein	Antitoxin
EDD84_RS18080	3802633..3802896	-	264	WP_013698802.1	PAAR domain-containing protein	-
EDD84_RS18085	3802963..3803378	-	416	Protein_3357	hypothetical protein	-
EDD84_RS18090	3803440..3805455	-	2016	WP_036040956.1	VC_2705 family sodium/solute symporter	-
EDD84_RS18095	3805449..3805886	-	438	WP_052143185.1	DUF4212 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (8-179)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-61)

Sequences

Toxin

Protein

• Length: 195 a.a.
• Molecular weight: 21425.17 Da
• Isoelectric Point: 4.9992

>T113697 WP_036040953.1 NZ_CP033430:c3801787-3801203 [Burkholderia gladioli]
MDDALINARLDFLRGCERLKDVLRSGHTSGGRRESTAEHSWRLALMAMVLMDQLGEVDPGRVLELCLVHDLGEALGGDVP
APEQAPGSDKDAVERRDLLRLGDALDAPMRERIVALWDEYARAATPEARAVKALDKIETILQHTQGENPPDFDYAFNLAY
GQAHTRKVPALQRFRERLDEATRERMAGAGGPSG

Nucleotide

• Length: 585 bp

>T113697 NZ_CP033430:c3801787-3801203 [Burkholderia gladioli]
ATGGACGACGCGTTGATCAACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAGGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGTAGCGACAAGGATGCCGTCGAGCGACGCGATCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCGCGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAACCTCGCGTAT
GGGCAGGCGCATACCCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCCTCGACGAGGCGACGCGCGAGCGGATGGC
CGGTGCTGGCGGGCCTTCGGGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20126.89 Da
• Isoelectric Point: 8.7110

>AT113697 WP_206427631.1 NZ_CP033430:c3802441-3801890 [Burkholderia gladioli]
MPLSALACSPGASLRRWRTLRRIKQEHAAALFGVSQSTISRWEAGTQAVSHEELRRIEACLSARLDSAADRALERLVSHH
TRPVHLVCDLTHRLLACSTPRAAGFAAPLSSLMGASLWPFATAEIVAREQSLRDAGWHDHPAPSIEFDTGSNDSPQVPIR
ASRCRWTRFTLSDGTLARLVETL

Nucleotide

• Length: 552 bp

>AT113697 NZ_CP033430:c3802441-3801890 [Burkholderia gladioli]
TTGCCGCTGTCCGCGCTGGCCTGCTCGCCGGGCGCGAGCTTGCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACA
TGCGGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGCGCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAAC
TGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCGGCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCAC
ACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCTGCTGGCCTGCTCCACGCCGCGAGCCGCGGGGTTCGCGGC
GCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCGCGACGGCCGAGATCGTGGCGCGCGAGCAGTCCTTGCGCG
ATGCGGGCTGGCACGATCATCCGGCACCCTCGATCGAATTCGATACCGGGTCCAACGACTCGCCTCAGGTGCCGATTCGT
GCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGGAACGCTGGCGCGCCTGGTCGAAACGCTTTGA

Structures

Toxin

• AlphaFold DB: A0A3G3LAL0