Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 481326..481890 | Replicon | chromosome |
Accession | NZ_CP033427 | ||
Organism | Mycobacterium avium subsp. paratuberculosis strain MAPK_CN9/15 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | X7VBD8 |
Locus tag | EC390_RS02160 | Protein ID | WP_003875391.1 |
Coordinates | 481326..481697 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A7L5MGM2 |
Locus tag | EC390_RS02165 | Protein ID | WP_003875390.1 |
Coordinates | 481684..481890 (-) | Length | 69 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EC390_RS02115 | 476663..476860 | - | 198 | WP_016706054.1 | hypothetical protein | - |
EC390_RS02120 | 476978..477661 | + | 684 | WP_003875399.1 | hypothetical protein | - |
EC390_RS02125 | 477666..477990 | - | 325 | Protein_409 | antibiotic biosynthesis monooxygenase | - |
EC390_RS02130 | 478401..478925 | - | 525 | WP_033713819.1 | glycoside hydrolase | - |
EC390_RS02135 | 479082..479435 | - | 354 | WP_003875396.1 | hypothetical protein | - |
EC390_RS02140 | 479505..479888 | - | 384 | WP_003875395.1 | hypothetical protein | - |
EC390_RS02145 | 479955..480353 | - | 399 | WP_003875394.1 | VOC family protein | - |
EC390_RS02150 | 480455..480730 | - | 276 | WP_003878531.1 | hypothetical protein | - |
EC390_RS02155 | 480786..481226 | - | 441 | WP_010949694.1 | nitroreductase family deazaflavin-dependent oxidoreductase | - |
EC390_RS02160 | 481326..481697 | - | 372 | WP_003875391.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
EC390_RS02165 | 481684..481890 | - | 207 | WP_003875390.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
EC390_RS02170 | 482059..483003 | - | 945 | WP_003875389.1 | HNH endonuclease | - |
EC390_RS02175 | 483203..484276 | - | 1074 | WP_010949695.1 | redox-regulated ATPase YchF | - |
EC390_RS02180 | 484407..485615 | + | 1209 | WP_010949696.1 | hypothetical protein | - |
EC390_RS02185 | 485639..486637 | - | 999 | WP_003875386.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13770.14 Da Isoelectric Point: 6.6003
>T113685 WP_003875391.1 NZ_CP033427:c481697-481326 [Mycobacterium avium subsp. paratuberculosis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL
Download Length: 372 bp
>T113685 NZ_CP033427:c481697-481326 [Mycobacterium avium subsp. paratuberculosis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGTTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGTTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA
Antitoxin
Download Length: 69 a.a. Molecular weight: 7231.22 Da Isoelectric Point: 11.0634
>AT113685 WP_003875390.1 NZ_CP033427:c481890-481684 [Mycobacterium avium subsp. paratuberculosis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRAPADDSR
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRAPADDSR
Download Length: 207 bp
>AT113685 NZ_CP033427:c481890-481684 [Mycobacterium avium subsp. paratuberculosis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGGCACCCGCCGATGATTCTCGTTGA
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGGCACCCGCCGATGATTCTCGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E2WB37 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7L5MGM2 |