Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 35640..36162 Replicon plasmid pCFSA1007-2
Accession NZ_CP033386
Organism Salmonella enterica subsp. enterica strain CFSA1007

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag ECB87_RS01175 Protein ID WP_000220561.1
Coordinates 35881..36162 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag ECB87_RS01170 Protein ID WP_000121743.1
Coordinates 35640..35891 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECB87_RS01150 31763..32185 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
ECB87_RS01155 32253..32699 - 447 WP_001074384.1 hypothetical protein -
ECB87_RS01160 32703..33545 - 843 WP_000435064.1 replication initiation protein -
ECB87_RS01165 33566..34405 - 840 WP_024129959.1 replication initiation protein -
ECB87_RS01170 35640..35891 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
ECB87_RS01175 35881..36162 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECB87_RS01180 36401..36493 - 93 Protein_43 IS6 family transposase -
ECB87_RS01185 36659..37858 - 1200 WP_000948429.1 IS91 family transposase -
ECB87_RS01190 37868..38056 - 189 WP_000957857.1 hypothetical protein -
ECB87_RS01195 38176..39606 + 1431 Protein_46 IS4-like element IS50R family transposase -
ECB87_RS01200 39635..40429 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
ECB87_RS01205 40450..40686 + 237 Protein_48 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..52902 52902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T113604 WP_000220561.1 NZ_CP033386:35881-36162 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T113604 NZ_CP033386:35881-36162 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT113604 WP_000121743.1 NZ_CP033386:35640-35891 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT113604 NZ_CP033386:35640-35891 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References