Detailed information of TA system TA113603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 18719..19362
• Replicon: plasmid pCFSA1007-2
• Accession: NZ_CP033386
• Organism: Salmonella enterica subsp. enterica strain CFSA1007

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: B1LRW4
• Locus tag: ECB87_RS01080
• Protein ID: WP_001044768.1
• Coordinates: 18719..19135 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: D2WFK3
• Locus tag: ECB87_RS01085
• Protein ID: WP_001261287.1
• Coordinates: 19132..19362 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECB87_RS01065	15218..15808	-	591	WP_000194575.1	hypothetical protein	-
ECB87_RS01070	15808..16065	-	258	WP_000343085.1	hypothetical protein	-
ECB87_RS01075	16419..18557	+	2139	WP_000350638.1	AAA family ATPase	-
ECB87_RS01080	18719..19135	-	417	WP_001044768.1	type II toxin-antitoxin system VapC family toxin	Toxin
ECB87_RS01085	19132..19362	-	231	WP_001261287.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ECB87_RS01090	19658..19948	+	291	WP_000111771.1	hypothetical protein	-
ECB87_RS01095	19938..20837	+	900	WP_000963206.1	nucleotide-binding protein	-
ECB87_RS01100	20887..23112	-	2226	WP_000698737.1	phage T7 exclusion protein	-
ECB87_RS01105	23114..24202	-	1089	WP_000952217.1	transcriptional repressor PifC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..52902	52902

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (16-56)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 20475.56 Da
• Isoelectric Point: 5.5500

>T113603 WP_001044768.1 NZ_CP033386:c19135-18719 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 417 bp

>T113603 NZ_CP033386:c19135-18719 [Salmonella enterica subsp. enterica]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT113603 WP_001261287.1 NZ_CP033386:c19362-19132 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT113603 NZ_CP033386:c19362-19132 [Salmonella enterica subsp. enterica]
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Structures

Toxin

• AlphaFold DB: A0A606Q844

Antitoxin

• AlphaFold DB: A0A7U9QFC4