Detailed information of TA system TA113595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3974787..3975364
• Replicon: chromosome
• Accession: NZ_CP033381
• Organism: Methylomonas sp. LW13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JL719_RS17880
• Protein ID: WP_033155806.1
• Coordinates: 3974787..3974972 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JL719_RS17885
• Protein ID: WP_033155611.1
• Coordinates: 3974969..3975364 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL719_RS17865	3970186..3970569	-	384	WP_129871428.1	hypothetical protein	-
JL719_RS17870	3970701..3973799	+	3099	WP_129871477.1	class I SAM-dependent DNA methyltransferase	-
JL719_RS17875	3973807..3974703	+	897	WP_033155610.1	hypothetical protein	-
JL719_RS17880	3974787..3974972	+	186	WP_033155806.1	type II toxin-antitoxin system HicA family toxin	Toxin
JL719_RS17885	3974969..3975364	+	396	WP_033155611.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JL719_RS17890	3975368..3976621	-	1254	WP_033155612.1	tyrosine-type recombinase/integrase	-
JL719_RS17900	3976909..3977310	-	402	WP_171696150.1	preprotein translocase subunit SecG	-
JL719_RS17905	3977332..3978078	-	747	WP_033155613.1	triose-phosphate isomerase	-
JL719_RS17910	3978133..3979473	-	1341	WP_033155614.1	phosphoglucosamine mutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3960184..3981464	21280

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6728.96 Da
• Isoelectric Point: 11.0075

>T113595 WP_033155806.1 NZ_CP033381:3974787-3974972 [Methylomonas sp. LW13]
MNSRQLIKLLEDDGWTLRSVKGSHHVFVHPVKPGHLTVPHPKSDLGKGLVSKLLKQAGLKV

Nucleotide

• Length: 186 bp

>T113595 NZ_CP033381:3974787-3974972 [Methylomonas sp. LW13]
ATGAATAGCAGGCAACTGATCAAGCTACTTGAAGATGACGGGTGGACGCTGCGTAGCGTTAAAGGCAGTCATCATGTCTT
TGTTCACCCGGTTAAGCCGGGACATTTGACAGTGCCGCATCCCAAAAGTGATTTAGGCAAAGGATTGGTGAGTAAGCTGT
TAAAACAAGCGGGGTTGAAGGTATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14371.36 Da
• Isoelectric Point: 4.4277

>AT113595 WP_033155611.1 NZ_CP033381:3974969-3975364 [Methylomonas sp. LW13]
MRFFVAIEPGDKDHAFGVVVPDLPGCFSAGDTLDEAFENAKEAIDLWCETVIEDGAMIPPGKTLAEHQADPEFAGWVWSI
VEVPVERYLGPAEKVNITLPKLLLTRIDEYAKAHGSTRSGFLAQAARQAMR

Nucleotide

• Length: 396 bp

>AT113595 NZ_CP033381:3974969-3975364 [Methylomonas sp. LW13]
ATGAGATTTTTTGTTGCGATTGAGCCAGGTGATAAGGATCATGCTTTTGGCGTAGTGGTGCCCGATTTGCCAGGTTGCTT
TTCGGCAGGCGACACCCTGGACGAGGCATTCGAAAACGCAAAAGAAGCCATTGATTTATGGTGCGAAACAGTTATCGAAG
ATGGTGCAATGATTCCACCCGGCAAAACGCTAGCGGAACATCAAGCAGACCCAGAATTTGCTGGTTGGGTGTGGTCTATC
GTAGAGGTGCCGGTAGAACGGTATTTAGGCCCCGCCGAGAAGGTCAATATTACATTGCCTAAGCTGTTGCTGACTCGTAT
TGACGAATACGCCAAAGCTCACGGCTCTACCCGTTCCGGGTTCTTGGCTCAAGCCGCCCGGCAGGCGATGCGTTAA