Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3964737..3965314 Replicon chromosome
Accession NZ_CP033381
Organism Methylomonas sp. LW13

Toxin (Protein)


Gene name hicA Uniprot ID A0A2N0V3H5
Locus tag JL719_RS17825 Protein ID WP_033155802.1
Coordinates 3964737..3964922 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N0V2Y5
Locus tag JL719_RS17830 Protein ID WP_033155605.1
Coordinates 3964919..3965314 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL719_RS17810 3959879..3960184 - 306 WP_033155601.1 DUF1016 family protein -
JL719_RS17815 3960184..3961656 - 1473 WP_033155602.1 type I restriction-modification system subunit M -
JL719_RS17820 3961759..3964122 - 2364 WP_033155603.1 DEAD/DEAH box helicase family protein -
JL719_RS17825 3964737..3964922 + 186 WP_033155802.1 type II toxin-antitoxin system HicA family toxin Toxin
JL719_RS17830 3964919..3965314 + 396 WP_033155605.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JL719_RS17835 3965318..3966063 - 746 Protein_3523 site-specific integrase -
JL719_RS17840 3966439..3967017 - 579 WP_033155606.1 hypothetical protein -
JL719_RS17845 3967254..3967556 - 303 WP_033155607.1 hypothetical protein -
JL719_RS17850 3967556..3969289 - 1734 WP_051669683.1 hypothetical protein -
JL719_RS17855 3969286..3969666 - 381 WP_203531399.1 DNA primase -
JL719_RS17860 3969768..3969998 - 231 WP_033155608.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3960184..3981464 21280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6911.18 Da        Isoelectric Point: 11.0007

>T113594 WP_033155802.1 NZ_CP033381:3964737-3964922 [Methylomonas sp. LW13]
MNSRQLIKLLEDDGWTLRSVKGSHHIFVHPVKPGHLTVPHPKRDLGKGLVNKLLKQAELKV

Download         Length: 186 bp

>T113594 NZ_CP033381:3964737-3964922 [Methylomonas sp. LW13]
ATGAATAGCAGGCAACTAATCAAGCTACTTGAAGATGATGGGTGGACGCTGCGTAGCGTTAAAGGTAGTCATCACATCTT
TGTTCACCCGGTTAAGCCGGGGCATTTGACGGTGCCGCATCCAAAGCGCGATTTAGGCAAAGGGTTGGTAAACAAGCTGT
TAAAACAAGCGGAGTTGAAGGTATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14369.35 Da        Isoelectric Point: 4.3410

>AT113594 WP_033155605.1 NZ_CP033381:3964919-3965314 [Methylomonas sp. LW13]
MRFFVAIEPGDEDHAFGVVVPDLPGCFSAGDTLDEAFENAKEAIDLWCETVIEDGAMIPPGKTLAEHQANPEFAGWVWSI
VEVPVERYLGPAEKINITLPKLLLTRIDEYAKAHGATRSGFLAQAARQAMR

Download         Length: 396 bp

>AT113594 NZ_CP033381:3964919-3965314 [Methylomonas sp. LW13]
ATGAGATTTTTTGTTGCGATAGAACCAGGTGATGAGGATCATGCTTTTGGCGTAGTGGTGCCCGATTTGCCGGGTTGCTT
TTCGGCAGGCGACACCCTGGACGAGGCATTCGAAAACGCGAAAGAAGCCATTGATCTATGGTGCGAAACAGTTATCGAAG
ATGGTGCAATGATTCCACCCGGCAAAACGCTAGCGGAACACCAAGCAAACCCAGAATTTGCCGGATGGGTGTGGTCTATC
GTAGAAGTGCCGGTAGAACGGTATTTAGGCCCAGCCGAGAAGATCAATATTACATTGCCTAAGCTGTTGCTGACTCGTAT
TGACGAATACGCCAAAGCTCATGGCGCTACCCGTTCCGGGTTCTTGGCTCAAGCCGCGCGGCAGGCGATGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N0V3H5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V2Y5

References