Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3369687..3370267 Replicon chromosome
Accession NZ_CP033381
Organism Methylomonas sp. LW13

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JL719_RS15195 Protein ID WP_033155171.1
Coordinates 3369687..3370013 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JL719_RS15200 Protein ID WP_033155172.1
Coordinates 3370010..3370267 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL719_RS15175 3364723..3365664 + 942 WP_033159502.1 MoxR family ATPase -
JL719_RS15180 3365667..3366428 + 762 WP_033159503.1 hypothetical protein -
JL719_RS15185 3366551..3367759 + 1209 WP_033155170.1 DUF3150 domain-containing protein -
JL719_RS15190 3367844..3369667 + 1824 WP_033155731.1 VWA domain-containing protein -
JL719_RS15195 3369687..3370013 - 327 WP_033155171.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JL719_RS15200 3370010..3370267 - 258 WP_033155172.1 antitoxin Antitoxin
JL719_RS15205 3370599..3371132 + 534 WP_033155173.1 hypothetical protein -
JL719_RS15210 3371110..3371484 - 375 WP_033155174.1 hypothetical protein -
JL719_RS15215 3371650..3372312 + 663 WP_033155175.1 hypothetical protein -
JL719_RS15220 3372462..3372959 + 498 WP_033155176.1 hypothetical protein -
JL719_RS15225 3373295..3374410 + 1116 WP_033155177.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3349931..3382454 32523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11814.69 Da        Isoelectric Point: 6.9787

>T113593 WP_033155171.1 NZ_CP033381:c3370013-3369687 [Methylomonas sp. LW13]
MKRGDIYLVSLDPTAGHEQKGSRPVVIVSPDEFNQVTKLPVVLPITTGGDFARRLGFAVPLTGIKTTGVIRCDQPRILDL
AARQARWVDSVPDAIMDDVLARLSTLFE

Download         Length: 327 bp

>T113593 NZ_CP033381:c3370013-3369687 [Methylomonas sp. LW13]
ATGAAGCGCGGCGACATCTATTTGGTTTCACTCGATCCGACCGCAGGCCATGAACAAAAAGGCAGCCGGCCGGTGGTCAT
CGTGTCCCCGGATGAATTCAATCAGGTCACCAAACTGCCGGTGGTATTACCGATCACCACGGGCGGTGATTTCGCGCGGC
GCCTGGGATTTGCGGTTCCGTTGACGGGAATCAAAACCACCGGTGTGATTCGCTGCGACCAACCGCGTATCCTCGATTTG
GCGGCTCGCCAAGCTCGATGGGTCGATAGCGTACCGGACGCCATCATGGATGACGTGCTGGCACGACTATCGACCTTGTT
CGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9192.52 Da        Isoelectric Point: 4.7063

>AT113593 WP_033155172.1 NZ_CP033381:c3370267-3370010 [Methylomonas sp. LW13]
MHTTNLRKVGGSIMLAVPPALLEQLHLQAGATVGLVIDHGRLVVEPSPKPHYTLAELLANSDYSAPLSEEEREWIDTPAV
GNELL

Download         Length: 258 bp

>AT113593 NZ_CP033381:c3370267-3370010 [Methylomonas sp. LW13]
ATGCACACTACCAATCTACGTAAAGTCGGCGGCTCAATCATGTTGGCGGTGCCTCCGGCATTGTTGGAACAATTACACTT
GCAAGCCGGCGCGACGGTAGGCTTGGTTATCGATCACGGCCGTTTGGTCGTAGAGCCATCTCCGAAGCCGCATTACACCC
TGGCCGAATTACTGGCCAATTCAGACTATTCCGCACCACTGTCCGAAGAAGAGCGCGAATGGATCGATACGCCGGCGGTG
GGTAACGAACTGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References