Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2608780..2609354 Replicon chromosome
Accession NZ_CP033381
Organism Methylomonas sp. LW13

Toxin (Protein)


Gene name vapC Uniprot ID A0A2N0V9P6
Locus tag JL719_RS11725 Protein ID WP_033156234.1
Coordinates 2608780..2609148 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2N0V9S1
Locus tag JL719_RS11730 Protein ID WP_033156233.1
Coordinates 2609145..2609354 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL719_RS11705 2605180..2606055 + 876 WP_033156238.1 hypothetical protein -
JL719_RS11710 2606740..2607495 + 756 WP_129871391.1 hypothetical protein -
JL719_RS11715 2607495..2608007 + 513 WP_033156236.1 hypothetical protein -
JL719_RS11720 2608033..2608479 + 447 WP_033156235.1 hypothetical protein -
JL719_RS11725 2608780..2609148 - 369 WP_033156234.1 type II toxin-antitoxin system VapC family toxin Toxin
JL719_RS11730 2609145..2609354 - 210 WP_033156233.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JL719_RS11735 2609823..2611211 + 1389 WP_033156232.1 ATP-dependent RNA helicase DbpA -
JL719_RS11740 2611424..2612560 + 1137 WP_033156231.1 acyltransferase -
JL719_RS11745 2612597..2613454 + 858 WP_033156230.1 penicillin-insensitive murein endopeptidase -
JL719_RS11750 2613524..2613946 + 423 WP_033156229.1 HIT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13619.89 Da        Isoelectric Point: 5.1231

>T113591 WP_033156234.1 NZ_CP033381:c2609148-2608780 [Methylomonas sp. LW13]
MILVDTSVWVDHFKKCNEDLVRLLVSDSALIHPLIVAELACGTPPAPRTQTLNNLRQLRYCNQAGLQEVEDFIEREALYG
LGCGLIDLQLLASVLITPGAKLWTLDKRLAKLAERFGVDCWS

Download         Length: 369 bp

>T113591 NZ_CP033381:c2609148-2608780 [Methylomonas sp. LW13]
ATGATATTGGTCGATACCTCGGTTTGGGTTGACCATTTCAAAAAGTGCAACGAAGACCTGGTGCGTTTGCTTGTTTCCGA
TTCGGCGTTGATTCACCCGCTGATCGTTGCCGAATTGGCTTGCGGTACGCCGCCCGCGCCGAGAACCCAAACCCTGAACA
ACCTGCGTCAGCTAAGGTATTGCAATCAAGCCGGTTTGCAGGAAGTGGAAGACTTTATCGAACGTGAAGCACTATATGGC
TTGGGTTGCGGACTAATCGATTTGCAGTTGCTAGCCTCGGTTTTGATTACGCCCGGCGCCAAGCTGTGGACGTTGGACAA
GCGGTTGGCGAAACTTGCCGAGCGGTTTGGGGTGGATTGCTGGTCGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7654.83 Da        Isoelectric Point: 5.0338

>AT113591 WP_033156233.1 NZ_CP033381:c2609354-2609145 [Methylomonas sp. LW13]
MRTTVTIDDALYQKALEMADPGMDKTEIFREAMKTFVRIQAAKRLAALGGTLPEMADIPRERGQTEPSA

Download         Length: 210 bp

>AT113591 NZ_CP033381:c2609354-2609145 [Methylomonas sp. LW13]
ATGAGAACCACTGTAACCATAGACGATGCGTTGTACCAAAAGGCCCTGGAAATGGCTGATCCAGGTATGGATAAGACCGA
AATTTTCCGGGAAGCGATGAAAACCTTCGTCCGAATCCAGGCCGCCAAACGCTTGGCTGCCTTGGGCGGAACCCTACCGG
AGATGGCCGATATTCCCCGAGAACGCGGCCAAACCGAACCGTCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N0V9P6

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V9S1

References