Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2599186..2600678 Replicon chromosome
Accession NZ_CP033381
Organism Methylomonas sp. LW13

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A2N0V9P3
Locus tag JL719_RS11680 Protein ID WP_033156242.1
Coordinates 2599186..2600448 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A2N0V9P0
Locus tag JL719_RS11685 Protein ID WP_033156241.1
Coordinates 2600445..2600678 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL719_RS11660 2595116..2595709 - 594 WP_033156245.1 SRPBCC family protein -
JL719_RS11665 2595837..2597270 + 1434 WP_033156244.1 exodeoxyribonuclease I -
JL719_RS11670 2597381..2598562 + 1182 WP_033156243.1 pyridoxal phosphate-dependent aminotransferase -
JL719_RS11680 2599186..2600448 - 1263 WP_033156242.1 type II toxin-antitoxin system HipA family toxin Toxin
JL719_RS11685 2600445..2600678 - 234 WP_033156241.1 helix-turn-helix transcriptional regulator Antitoxin
JL719_RS11690 2600920..2601471 + 552 WP_033156240.1 hypothetical protein -
JL719_RS11695 2601706..2601879 - 174 WP_165385953.1 hypothetical protein -
JL719_RS11700 2602188..2605124 + 2937 WP_051669858.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 46360.33 Da        Isoelectric Point: 7.1439

>T113590 WP_033156242.1 NZ_CP033381:c2600448-2599186 [Methylomonas sp. LW13]
MSHLLAVYLFDRRVGDLALVEGRLQFSYCADWLQHADAVPLSCSLPLQVEVFNDQQTRPFFAGLLPEGKLRQLIARQFQV
SKQNDFALLDHIGGECAGAVSLLPPDRLPAVSEPANEIDWLSDSDVVALLDELPQRPMLAGRDGLRLSLAGAQDKLPVVF
DGQRIGLPRNGTPSSHILKPAIAAVEDSVINEGFCLALAGAMQFQTAQSRICAIRDRSFLLVERYDRTQTAIGQCVRLHQ
EDFCQALGVVPELKYQNEGGPGLERCFDLVRRVTRPSATQVLRLLDAVIFNALIGNHDAHAKNFSILYADKGAVLAPLYD
VLSTAVYPSLTPKMAMQLGGKYKFSEVQARHWDRFAQAAGLSVAQTRKRILGLCQRLPVVARRLQTSADHEFAGNPVIEQ
LVQLIEQRAALTVRRFAGFD

Download         Length: 1263 bp

>T113590 NZ_CP033381:c2600448-2599186 [Methylomonas sp. LW13]
ATGAGCCATTTGCTTGCTGTCTATTTATTTGATCGTCGAGTGGGGGATTTGGCCCTGGTTGAAGGCAGACTGCAATTTAG
CTACTGCGCCGACTGGCTGCAACATGCCGACGCTGTCCCGCTGTCCTGCTCGTTACCGTTGCAAGTAGAGGTTTTCAACG
ACCAACAGACGCGGCCTTTCTTTGCTGGATTGTTACCGGAAGGCAAATTACGCCAACTGATTGCTCGCCAGTTTCAGGTC
TCGAAGCAGAACGACTTTGCCTTGCTCGATCATATCGGCGGCGAATGCGCTGGTGCGGTTTCGCTATTGCCGCCAGACCG
ATTACCCGCTGTATCTGAACCAGCGAACGAGATCGACTGGTTATCCGACTCTGACGTAGTGGCCTTGCTGGATGAATTGC
CACAGCGGCCGATGCTGGCTGGTCGAGATGGCTTGCGCCTGTCCTTGGCGGGCGCTCAGGATAAGTTGCCGGTGGTATTT
GATGGTCAACGAATCGGTCTGCCCCGCAATGGCACGCCCAGTAGCCATATTCTCAAACCGGCCATCGCTGCCGTGGAAGA
CAGTGTAATCAACGAAGGTTTCTGTCTGGCATTGGCAGGTGCAATGCAATTCCAGACCGCACAGTCGAGGATTTGTGCCA
TTCGCGACCGCTCATTTTTGCTGGTTGAGCGTTATGACAGAACTCAAACTGCAATTGGCCAATGCGTGCGTCTGCATCAG
GAAGATTTCTGCCAGGCACTAGGCGTGGTACCGGAACTGAAATATCAGAACGAGGGTGGGCCGGGTTTGGAACGGTGCTT
CGATTTGGTCCGCCGCGTGACCCGACCGAGTGCGACGCAGGTGTTGCGACTGCTGGATGCGGTCATTTTCAATGCCTTGA
TTGGCAACCACGACGCCCATGCCAAGAACTTTTCTATCTTGTATGCCGACAAGGGTGCCGTTCTGGCGCCACTTTATGAC
GTCCTGTCAACCGCCGTTTATCCCAGTCTGACGCCCAAGATGGCAATGCAGTTGGGTGGCAAATATAAATTTAGCGAAGT
GCAGGCAAGACACTGGGACCGCTTTGCCCAAGCGGCGGGCTTGTCGGTAGCGCAAACCCGAAAACGCATTCTTGGTTTGT
GCCAACGGCTACCGGTGGTTGCTCGCAGGTTGCAGACATCGGCGGATCATGAATTTGCTGGAAACCCAGTGATTGAACAA
CTCGTACAGCTGATCGAGCAACGCGCGGCGCTGACGGTCAGGCGGTTCGCCGGGTTTGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8257.62 Da        Isoelectric Point: 4.6082

>AT113590 WP_033156241.1 NZ_CP033381:c2600678-2600445 [Methylomonas sp. LW13]
MINIQSTQQLGQALRSARKQLELTQSELALAAGVGVRFIVDLEAGKPTVRLETVMRVIEALGGQVMLDGLPDITEAP

Download         Length: 234 bp

>AT113590 NZ_CP033381:c2600678-2600445 [Methylomonas sp. LW13]
ATGATCAACATCCAATCTACCCAACAACTTGGCCAAGCGCTACGCTCTGCCCGCAAACAACTCGAATTAACTCAATCCGA
ACTAGCGTTGGCGGCAGGCGTGGGCGTTCGCTTTATCGTCGACCTCGAAGCAGGCAAGCCGACCGTGCGTCTGGAAACGG
TGATGCGCGTGATTGAAGCACTGGGTGGGCAGGTCATGCTCGATGGCCTGCCGGACATAACCGAAGCACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N0V9P3

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V9P0

References