Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 129235..129788 Replicon chromosome
Accession NZ_CP033381
Organism Methylomonas sp. LW13

Toxin (Protein)


Gene name parE Uniprot ID A0A2N0V4U3
Locus tag JL719_RS00530 Protein ID WP_033157536.1
Coordinates 129235..129525 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2N0V4T8
Locus tag JL719_RS00535 Protein ID WP_033157535.1
Coordinates 129528..129788 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL719_RS00505 124446..125684 + 1239 WP_033157541.1 methane monooxygenase/ammonia monooxygenase subunit B -
JL719_RS00510 125701..126474 + 774 WP_033157540.1 methane monooxygenase/ammonia monooxygenase subunit C -
JL719_RS00515 126857..128092 + 1236 WP_033157539.1 MFS transporter -
JL719_RS00520 128113..128493 + 381 WP_033157538.1 tautomerase family protein -
JL719_RS00525 128558..129064 + 507 WP_033157537.1 DUF1993 domain-containing protein -
JL719_RS00530 129235..129525 - 291 WP_033157536.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL719_RS00535 129528..129788 - 261 WP_033157535.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JL719_RS00540 129865..130337 + 473 Protein_107 MFS transporter -
JL719_RS00545 130940..132052 + 1113 WP_051670118.1 GTP-binding DUF697 domain-containing protein -
JL719_RS00550 132058..133149 + 1092 WP_051670117.1 GTPase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 120497..134948 14451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-92)

Antitoxin

Antitoxin ParD

(7-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11376.99 Da        Isoelectric Point: 8.0777

>T113585 WP_033157536.1 NZ_CP033381:c129525-129235 [Methylomonas sp. LW13]
MRKIHTQALAKQDLKNIWLYSFSNWGEVQADRYFDELNAAFALIAENPELGFACDYIREGYRQFHINRHLVFYRVTAAKI
HIVRVLHDSMNYTAQL

Download         Length: 291 bp

>T113585 NZ_CP033381:c129525-129235 [Methylomonas sp. LW13]
ATGCGCAAAATCCATACTCAGGCACTCGCAAAACAAGATCTAAAAAATATCTGGCTTTACTCATTTAGCAACTGGGGCGA
GGTGCAGGCGGATCGCTATTTTGATGAATTAAATGCGGCTTTCGCTTTAATCGCTGAAAATCCGGAATTGGGTTTTGCCT
GTGATTACATTCGTGAAGGGTACAGGCAATTCCACATCAATCGCCATTTAGTTTTTTATCGTGTTACAGCAGCCAAGATT
CATATTGTACGGGTGCTACATGACAGTATGAATTACACTGCGCAATTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9574.78 Da        Isoelectric Point: 4.8481

>AT113585 WP_033157535.1 NZ_CP033381:c129788-129528 [Methylomonas sp. LW13]
MAQARTQTVSLGEHWNNLIDSLLKSGRYASVSEIMRDSLRLLEEREANSKLQSLRTSLIQGEESGDAGELNMETIRLEAK
KEAGLV

Download         Length: 261 bp

>AT113585 NZ_CP033381:c129788-129528 [Methylomonas sp. LW13]
ATGGCTCAAGCGCGAACCCAAACCGTTAGCCTCGGCGAGCACTGGAATAACCTCATTGACTCTTTGCTCAAGAGTGGACG
CTATGCAAGCGTTAGTGAAATTATGCGTGACTCATTACGCTTGCTTGAGGAAAGAGAAGCGAACTCCAAATTGCAATCTT
TACGCACATCCCTAATTCAAGGTGAGGAGAGTGGCGATGCCGGCGAATTAAACATGGAAACAATCAGACTGGAAGCCAAA
AAAGAAGCCGGTTTAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N0V4U3

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V4T8

References