Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 722222..723012 Replicon chromosome
Accession NZ_CP033378
Organism Escherichia coli strain L73

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EB670_RS03545 Protein ID WP_122927273.1
Coordinates 722632..723012 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EB670_RS03540 Protein ID WP_122927272.1
Coordinates 722222..722581 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB670_RS03500 718062..718769 + 708 WP_122927265.1 transcriptional regulator -
EB670_RS24840 718774..718920 + 147 WP_164708656.1 hypothetical protein -
EB670_RS03505 718932..719147 + 216 WP_122927266.1 transposase -
EB670_RS03510 719296..719706 + 411 WP_122927267.1 hypothetical protein -
EB670_RS03515 719772..720713 + 942 WP_122927268.1 hypothetical protein -
EB670_RS03525 721017..721466 + 450 WP_122927269.1 antirestriction protein -
EB670_RS03530 721478..721957 + 480 WP_122927270.1 DNA repair protein RadC -
EB670_RS03535 721978..722199 + 222 WP_122927271.1 DUF987 domain-containing protein -
EB670_RS03540 722222..722581 + 360 WP_122927272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EB670_RS03545 722632..723012 + 381 WP_122927273.1 TA system toxin CbtA family protein Toxin
EB670_RS03550 723009..723500 + 492 WP_122927274.1 hypothetical protein -
EB670_RS03555 723590..724435 + 846 WP_122927275.1 DUF4942 domain-containing protein -
EB670_RS03565 724738..725244 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
EB670_RS03570 725323..727164 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14030.76 Da        Isoelectric Point: 6.8601

>T113562 WP_122927273.1 NZ_CP033378:722632-723012 [Escherichia coli]
MQTQSHSPERAARTCPSPVEIWQQLLTHLLDQHYGLTLNDTPFGNAGVIQEHISAGISLCDAVNFIVEKYDLVRTDRRGF
SVAEQSPLISSIDILRARRATGLMKRQGYRAVTDITTGQYSQESGQ

Download         Length: 381 bp

>T113562 NZ_CP033378:722632-723012 [Escherichia coli]
ATGCAAACACAATCCCACTCCCCGGAGCGGGCAGCCCGGACCTGCCCGTCACCCGTTGAAATCTGGCAGCAGCTTCTCAC
GCATCTGCTGGACCAGCACTACGGCCTCACGCTGAACGATACCCCATTTGGCAACGCTGGCGTCATTCAGGAACACATTA
GCGCCGGTATCTCCCTGTGCGACGCCGTGAATTTTATCGTCGAAAAATATGACCTTGTGCGCACTGACCGTCGCGGTTTC
TCCGTGGCGGAGCAATCACCATTAATCAGCAGTATCGATATACTTCGCGCCCGACGTGCCACCGGGCTGATGAAACGTCA
GGGCTACAGAGCCGTTACCGATATCACCACCGGGCAATATTCACAGGAGTCCGGGCAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13271.05 Da        Isoelectric Point: 6.3640

>AT113562 WP_122927272.1 NZ_CP033378:722222-722581 [Escherichia coli]
MPKTPNDTNHDIAEPWWGLQRNVTPCFGARLVQEGNRLHYLADRASITGTFSEAGLRHLDQAFPVLLKQLEMMLTCGELS
PHHQHCVTLYEKGLTCDADTLGSHGYVYMAIYPTPSTTA

Download         Length: 360 bp

>AT113562 NZ_CP033378:722222-722581 [Escherichia coli]
ATGCCAAAAACACCCAACGATACAAACCATGATATCGCTGAGCCCTGGTGGGGCCTGCAACGCAACGTCACTCCGTGCTT
TGGAGCCAGACTGGTGCAGGAGGGCAACCGGCTGCATTACCTGGCCGACCGCGCCAGTATCACTGGCACCTTCAGCGAGG
CGGGTTTACGTCATCTCGACCAGGCTTTCCCTGTATTGCTCAAACAACTGGAGATGATGCTCACCTGCGGTGAACTTAGC
CCGCACCACCAGCACTGTGTCACGCTGTATGAGAAAGGGCTGACATGCGACGCTGACACCCTCGGCTCGCATGGATACGT
GTATATGGCTATTTATCCGACACCCTCAACAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References