Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3648205..3648971 Replicon chromosome
Accession NZ_CP033368
Organism Mesorhizobium loti strain SU343

Toxin (Protein)


Gene name tacT Uniprot ID A0A6M7TS52
Locus tag EFV37_RS18005 Protein ID WP_064984294.1
Coordinates 3648486..3648971 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6M7TJG1
Locus tag EFV37_RS18000 Protein ID WP_064983733.1
Coordinates 3648205..3648486 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFV37_RS17975 3643558..3644538 + 981 WP_064983728.1 ABC transporter permease -
EFV37_RS17980 3644535..3645521 + 987 WP_019859204.1 ABC transporter permease -
EFV37_RS17985 3645638..3646186 + 549 WP_064983730.1 gluconokinase -
EFV37_RS17990 3646273..3646722 - 450 WP_019859201.1 Rrf2 family transcriptional regulator -
EFV37_RS17995 3646972..3647958 - 987 WP_064983732.1 sulfate ABC transporter substrate-binding protein -
EFV37_RS18000 3648205..3648486 + 282 WP_064983733.1 DUF1778 domain-containing protein Antitoxin
EFV37_RS18005 3648486..3648971 + 486 WP_064984294.1 GNAT family N-acetyltransferase Toxin
EFV37_RS18010 3649024..3650064 - 1041 WP_064983735.1 sulfate/molybdate ABC transporter ATP-binding protein -
EFV37_RS18015 3650134..3651018 - 885 WP_019859196.1 sulfate ABC transporter permease subunit CysW -
EFV37_RS18020 3651011..3651862 - 852 WP_019859195.1 sulfate ABC transporter permease subunit CysT -
EFV37_RS18025 3651947..3652975 - 1029 WP_019859193.1 sulfate ABC transporter substrate-binding protein -
EFV37_RS18030 3653180..3653911 - 732 WP_019859191.1 M15 family metallopeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(41-142)

Antitoxin

(3-79)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17185.84 Da        Isoelectric Point: 9.4412

>T113557 WP_064984294.1 NZ_CP033368:3648486-3648971 [Mesorhizobium loti]
MLSAPAPLAENHDLELFQSGTESLDQWLRRRARANQVGGASRTYVVAEGARVVGYYCLSSGGLDLAEAPGPIRRNMPDPI
PMVVLGRLAVDAGWQGKGLGAALLQDAVLRAGHAATILRIRGIFVHAISDEAKAFYEHYGFAASPKHPMTLVLSLKGLVK
A

Download         Length: 486 bp

>T113557 NZ_CP033368:3648486-3648971 [Mesorhizobium loti]
ATGCTATCGGCGCCGGCGCCCCTGGCCGAAAACCACGATCTCGAACTTTTCCAAAGTGGGACTGAAAGCCTCGACCAATG
GCTGCGCCGTAGGGCGCGGGCCAACCAAGTCGGTGGCGCGTCTCGGACTTATGTGGTGGCGGAAGGCGCTCGGGTTGTCG
GCTATTACTGCCTGTCTTCGGGCGGGCTTGATCTTGCGGAGGCGCCTGGCCCCATCCGTCGCAACATGCCGGATCCCATC
CCAATGGTCGTACTCGGGCGCCTTGCCGTGGACGCAGGCTGGCAAGGCAAGGGGCTGGGTGCCGCGCTACTGCAAGACGC
CGTTCTGCGCGCCGGCCACGCCGCGACGATCCTCAGGATTCGCGGCATTTTCGTTCATGCCATATCGGATGAGGCGAAAG
CCTTCTACGAGCACTACGGCTTCGCGGCTTCTCCGAAGCATCCAATGACCTTGGTGCTATCGTTGAAGGGCCTGGTGAAA
GCTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10709.28 Da        Isoelectric Point: 8.5038

>AT113557 WP_064983733.1 NZ_CP033368:3648205-3648486 [Mesorhizobium loti]
MTKAAPENHAKPVNLRIREDMRILIDRAAKIRGKTRSDFMIDAAYRSAEETLLDQTLIKVDPESYRHYLDILDKPPSGEG
FARLMNAPKPWQD

Download         Length: 282 bp

>AT113557 NZ_CP033368:3648205-3648486 [Mesorhizobium loti]
ATGACAAAGGCCGCCCCTGAGAACCACGCCAAGCCTGTCAATCTGCGTATCCGAGAGGACATGCGCATACTAATTGACCG
CGCCGCGAAAATACGCGGGAAAACCCGCTCCGACTTCATGATCGACGCCGCCTACCGTTCGGCTGAGGAGACGCTGCTCG
ACCAGACCCTGATCAAGGTGGATCCGGAGAGTTACCGGCATTATCTCGACATCCTTGACAAACCGCCAAGCGGGGAGGGT
TTTGCGCGCCTTATGAACGCGCCCAAGCCATGGCAGGACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6M7TS52


Antitoxin

Source ID Structure
AlphaFold DB A0A6M7TJG1

References