Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3396333..3397006 Replicon chromosome
Accession NZ_CP033365
Organism Mesorhizobium sp. NZP2298

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EB231_RS16515 Protein ID WP_206681928.1
Coordinates 3396605..3397006 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EB231_RS16510 Protein ID WP_172349739.1
Coordinates 3396333..3396608 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB231_RS16485 3391541..3392527 + 987 WP_172349735.1 ABC transporter permease -
EB231_RS16490 3392644..3393192 + 549 WP_172349736.1 AAA family ATPase -
EB231_RS16495 3393187..3394323 - 1137 WP_172349737.1 hypothetical protein -
EB231_RS16500 3394422..3394871 - 450 WP_027029809.1 Rrf2 family transcriptional regulator -
EB231_RS16505 3395122..3396108 - 987 WP_172349738.1 sulfate ABC transporter substrate-binding protein -
EB231_RS16510 3396333..3396608 + 276 WP_172349739.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EB231_RS16515 3396605..3397006 + 402 WP_206681928.1 PIN domain-containing protein Toxin
EB231_RS16520 3397022..3398062 - 1041 WP_172349741.1 TOBE-like domain-containing protein -
EB231_RS16525 3398076..3398960 - 885 WP_172349742.1 sulfate ABC transporter permease subunit CysW -
EB231_RS16530 3398953..3399804 - 852 WP_172349743.1 sulfate ABC transporter permease subunit CysT -
EB231_RS16535 3399876..3400904 - 1029 WP_056571863.1 sulfate ABC transporter substrate-binding protein -
EB231_RS16540 3401114..3401842 - 729 WP_172349744.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14296.69 Da        Isoelectric Point: 5.1971

>T113547 WP_206681928.1 NZ_CP033365:3396605-3397006 [Mesorhizobium sp. NZP2298]
MMRFMLDTNIISDMIRNPAGKAASAMVREGDAAVCTSIVVASELRYGCARKGSAKLLKKVEDLLAEIPVLPLDVPVDAEY
GALRAELESVGQPIGHNDLFIAAHACVLGTTLVTANIGEFTRIGKLKVENWLE

Download         Length: 402 bp

>T113547 NZ_CP033365:3396605-3397006 [Mesorhizobium sp. NZP2298]
TTGATGCGGTTCATGCTGGATACGAACATTATCAGCGACATGATCCGCAACCCGGCCGGCAAGGCCGCCAGTGCAATGGT
GCGCGAAGGAGACGCGGCTGTTTGCACCAGCATCGTCGTCGCCTCTGAATTGCGATATGGCTGCGCCAGGAAGGGGTCGG
CCAAGCTCCTCAAGAAGGTCGAGGACCTGCTGGCCGAGATCCCTGTCTTGCCACTCGACGTGCCCGTGGATGCCGAGTAC
GGCGCACTTCGCGCCGAGTTGGAGTCCGTTGGCCAACCCATTGGCCACAATGACCTTTTTATTGCCGCTCACGCCTGTGT
ATTGGGTACCACGCTGGTGACGGCCAATATTGGGGAGTTCACCCGGATAGGGAAGCTGAAGGTCGAGAACTGGCTGGAAT
AG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10267.78 Da        Isoelectric Point: 5.1891

>AT113547 WP_172349739.1 NZ_CP033365:3396333-3396608 [Mesorhizobium sp. NZP2298]
MPQHRHSTTPPPKEAKLFRNNRSQAVRIPVEFELPGEKVLISREGDRLVIEPLRKPGLTALLAQWAKEPPLGPEDDFPEI
KDAPVEAEDIL

Download         Length: 276 bp

>AT113547 NZ_CP033365:3396333-3396608 [Mesorhizobium sp. NZP2298]
ATGCCCCAACACCGTCATTCAACAACGCCGCCACCGAAGGAGGCGAAGCTGTTCCGCAACAATCGCAGCCAGGCGGTGCG
CATTCCTGTCGAGTTCGAGCTTCCCGGCGAGAAGGTTCTGATCAGCCGCGAAGGCGACCGCCTTGTCATCGAGCCGCTCC
GCAAACCCGGCCTTACCGCGCTGCTCGCCCAATGGGCGAAAGAGCCACCGCTTGGTCCTGAGGACGACTTTCCCGAGATC
AAGGATGCGCCCGTTGAAGCTGAGGACATTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References