Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3238420..3239093 Replicon chromosome
Accession NZ_CP033364
Organism Mesorhizobium sp. NZP2234

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EB230_RS15985 Protein ID WP_172373190.1
Coordinates 3238695..3239093 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EB230_RS15980 Protein ID WP_172373188.1
Coordinates 3238420..3238695 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB230_RS15955 3233639..3234625 + 987 WP_155772460.1 ABC transporter permease -
EB230_RS15960 3234742..3235290 + 549 WP_172373183.1 AAA family ATPase -
EB230_RS15965 3235285..3236421 - 1137 WP_172373185.1 hypothetical protein -
EB230_RS15970 3236521..3236970 - 450 WP_027029809.1 Rrf2 family transcriptional regulator -
EB230_RS15975 3237209..3238195 - 987 WP_172373187.1 sulfate ABC transporter substrate-binding protein -
EB230_RS15980 3238420..3238695 + 276 WP_172373188.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EB230_RS15985 3238695..3239093 + 399 WP_172373190.1 PIN domain-containing protein Toxin
EB230_RS15990 3239110..3240150 - 1041 WP_056571856.1 sulfate/molybdate ABC transporter ATP-binding protein -
EB230_RS15995 3240164..3241048 - 885 WP_056571857.1 sulfate ABC transporter permease subunit CysW -
EB230_RS16000 3241041..3241892 - 852 WP_056571860.1 sulfate ABC transporter permease subunit CysT -
EB230_RS16005 3241976..3243004 - 1029 WP_056571863.1 sulfate ABC transporter substrate-binding protein -
EB230_RS16010 3243216..3243938 - 723 WP_172373191.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(18-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14179.59 Da        Isoelectric Point: 7.1079

>T113546 WP_172373190.1 NZ_CP033364:3238695-3239093 [Mesorhizobium sp. NZP2234]
MRFMLDTNVISDMIRNPAGKAASAMVREGDAAVCTSIVVASELRYGCARKGSAKLLKKVEDLLAEIPVLPLDVPVDAEYG
ALRAELEAAGQPIGHNDLFIAAHACVMGTTLVTANVGKFARIRKLKVENWLE

Download         Length: 399 bp

>T113546 NZ_CP033364:3238695-3239093 [Mesorhizobium sp. NZP2234]
ATGCGGTTCATGTTGGATACAAACGTCATTAGCGACATGATCCGAAACCCGGCCGGCAAGGCTGCCAGTGCAATGGTGCG
CGAAGGTGACGCCGCTGTTTGCACCAGCATCGTCGTCGCCTCCGAATTGCGATATGGCTGCGCCAGGAAGGGATCGGCCA
AGCTGCTCAAGAAGGTCGAGGATCTGCTGGCCGAGATCCCTGTATTGCCGCTCGACGTACCGGTGGACGCTGAATACGGC
GCGCTTCGCGCCGAGTTGGAGGCCGCTGGCCAACCCATTGGCCACAATGACCTTTTTATTGCCGCTCACGCCTGCGTGAT
GGGCACCACATTGGTGACGGCCAATGTGGGGAAGTTCGCCCGGATACGGAAGCTGAAGGTCGAGAACTGGCTGGAATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10127.59 Da        Isoelectric Point: 5.7252

>AT113546 WP_172373188.1 NZ_CP033364:3238420-3238695 [Mesorhizobium sp. NZP2234]
VPQHRHTTASPPKEAKLFRNNRSQAVRIPVEFELPGDKVLISREGDRLVIEPLRKPGLAALLAQWAKEPPLGPEDDFPGI
KDAPVEAEDIF

Download         Length: 276 bp

>AT113546 NZ_CP033364:3238420-3238695 [Mesorhizobium sp. NZP2234]
GTGCCACAGCACCGGCATACAACCGCGTCGCCTCCGAAGGAGGCCAAGCTCTTCCGCAACAACCGCAGCCAGGCGGTGCG
TATTCCCGTCGAATTCGAGCTCCCCGGTGACAAGGTTCTGATCAGCCGCGAAGGCGACCGCCTTGTCATCGAGCCGCTCC
GCAAACCAGGCCTTGCCGCGCTGCTCGCCCAATGGGCGAAAGAGCCACCGCTTGGTCCTGAGGACGACTTTCCCGGGATC
AAGGATGCGCCTGTTGAAGCCGAGGACATTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References